Synthesis and antifungal activity of novel (1-arylmethyl-3-aryl-1H-pyrazol-5-yl)(4-arylpiperazin-1-yl) methanone derivatives

被引：4

作者：

Lv, Hong-Shui ^{[1
]}

Wang, Li-Ying ^{[2
]}

Ding, Xiao-Ling ^{[3
]}

Wang, Xiu-Hua ^{[2
]}

Zhao, Bao-Xiang ^{[1
]}

Zuo, Hua ^{[2
]}

机构：

[1] Shandong Univ, Inst Organ Chem, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China

[3] Qingdao Univ, Coll Adv Profess Technol, Qingdao 266061, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2013年 / 08期

关键词：

synthesis; pyrazole carboxamide; piperazine; antifungal activity; LUNG-CANCER CELLS; PYRAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; POTENTIAL AGENTS; INHIBITORS; DESIGN;

D O I：

10.3184/174751913X13734652599909

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel (1-arylmethyl-3-aryl-1H-pyrazol-5-yl)(4-arylpiperazin-1-yl) methanone derivatives were synthesised. Preliminary study of the structure-activity relationship revealed that 4-chlorophenyl, 4-tert-butylphenyl, 4-fluorophenyl and 3-methoxyphenyl had a promising effect on the antifungal activity.

引用

页码：473 / 475

页数：3

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