The Relationship of NT-proBNP and Dialysis Parameters with Outcome of Incident Haemodialysis Patients: Results from the Membrane Permeability Outcome Study

被引：9

作者：

Locatelli, Francesco ^{[1
]}

Hannedouche, Thierry ^{[2
]}

Martin-Malo, Alejandro ^{[3
]}

Jacobson, Stefan H. ^{[4
]}

Vanholder, Raymond ^{[5
]}

Ronco, Claudio ^{[6
]}

La Milia, Vincenzo ^{[1
]}

Lopez Gomez, Juan M. ^{[7
]}

Stefoni, Sergio ^{[8
]}

Maheut, Herve ^{[9
]}

Klinger, Marian ^{[10
]}

Krummel, Thierry ^{[2
]}

Dhondt, Annemie ^{[5
]}

Berdud, Isabel ^{[3
]}

Gauly, Adelheid ^{[11
]}

机构：

[1] Alessandro Manzoni Hosp, Dept Nephrol Dialysis & Renal Transplantat, IT-23900 Lecce, Italy

[2] Univ Hosp, Dept Nephrol, Strasbourg, France

[3] Univ Hosp Reina Sofia, Dept Nephrol, Cordoba, Spain

[4] Karolinska Inst, Dept Nephrol, Danderyd Univ Hosp, Stockholm, Sweden

[5] Univ Hosp, Dept Internal Med, Nephrol Sect, Ghent, Belgium

[6] St Bortolo Hosp, Dept Nephrol & Intens Care, Vicenza, Italy

[7] Hosp Gen Gregorio Maranon, Dept Nephrol, Madrid, Spain

[8] St Orsola Marcello Malpighi Hosp, Dept Nephrol Dialysis & Renal Transplantat, Bologna, Italy

[9] Univ Hosp Reims, Dept Nephrol, Reims, France

[10] Wroclaw Med Univ, Dept Nephrol & Transplantat Med, Wroclaw, Poland

[11] Fresenius Med Care, Clin Res, Bad Homburg, Germany

来源：

BLOOD PURIFICATION | 2013年 / 35卷 / 1-3期

关键词：

NT-proBNP; BNP; Cardiovascular diseases; Haemodialysis; Mortality; High flux membrane; Randomised trials; BRAIN NATRIURETIC PEPTIDE; STAGE RENAL-DISEASE; HEART-FAILURE; INDEPENDENT PREDICTOR; CARDIAC BIOMARKERS; TERMINAL PROBNP; FLUID OVERLOAD; MORTALITY; BNP; MARKER;

D O I：

10.1159/000347076

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Aims: The association of raised levels of natriuretic peptides with elevated risk of mortality was investigated in the present analysis of the Membrane Permeability Outcome study. Methods: N-terminal probrain type natriuretic peptide (NT-proBNP) was measured in 618 incident haemodialysis patients, randomised to either high-flux or low-flux. Characteristics of patients with NT-proBNP levels below or above the median were descriptively analysed and survival analysis was performed. Results: Median NT-proBNP value was 2,124 pg/ml, with 1,854 pg/ml in the high-flux and 2,919 pg/ml in the low-flux group. Survival probability was lowest in patients with both a history of cardiovascular disease and NT-proBNP values above the median (p < 0.001). A multivariate Cox proportional hazard model showed interaction between presence of cardiovascular diseases and NT-proBNP levels above the median. Conclusions: NT-proBNP is an independent predictor of mortality also in incident haemodialysis patients. Lower concentrations associated with high-flux dialysis suggest a possible biological link to improved survival in this group. Copyright (C) 2013 S. Karger AG, Basel

引用

页码：216 / 223

页数：8

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