Loss of heterozygosity of the APC gene in oral squamous cell carcinoma

被引：4
作者：
Rivero, Elena R. C. [1 ]
Horta, Martinho C. R. [2 ]
Guerrae, Eliete N. Silva [3 ]
Ferraz, Alberto R. [4 ]
Nunes, Fabio D. [5 ]
机构：
[1] Univ Fed Santa Catarina, Hlth Sci Ctr, Dept Pathol, BR-88040370 Florianopolis, SC, Brazil
[2] Pontificia Univ Catolica Minas Gerais, Sch Dent, Belo Horizonte, MG, Brazil
[3] Univ Brasilia, Sch Hlth Sci, Dept Dent, Brasilia, DF, Brazil
[4] Univ Sao Paulo, Sch Med, Dept Head & Neck Surg, Sao Paulo, Brazil
[5] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, Sao Paulo, Brazil
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2008年 / 204卷 / 11期
基金：
巴西圣保罗研究基金会;
关键词：
LOH; Genes; APC; Carcinoma; Squamous cell; PCR; RFLP;
D O I：
10.1016/j.prp.2008.05.003
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC. (C) 2008 Elsevier GmbH. All rights reserved.
引用
收藏
页码：793 / 797
页数：5
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