Loss of heterozygosity of the APC gene in oral squamous cell carcinoma

被引：4

作者：

Rivero, Elena R. C. ^{[1
]}

Horta, Martinho C. R. ^{[2
]}

Guerrae, Eliete N. Silva ^{[3
]}

Ferraz, Alberto R. ^{[4
]}

Nunes, Fabio D. ^{[5
]}

机构：

[1] Univ Fed Santa Catarina, Hlth Sci Ctr, Dept Pathol, BR-88040370 Florianopolis, SC, Brazil

[2] Pontificia Univ Catolica Minas Gerais, Sch Dent, Belo Horizonte, MG, Brazil

[3] Univ Brasilia, Sch Hlth Sci, Dept Dent, Brasilia, DF, Brazil

[4] Univ Sao Paulo, Sch Med, Dept Head & Neck Surg, Sao Paulo, Brazil

[5] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, Sao Paulo, Brazil

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2008年 / 204卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

LOH; Genes; APC; Carcinoma; Squamous cell; PCR; RFLP;

D O I：

10.1016/j.prp.2008.05.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：793 / 797

页数：5

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