Loss of heterozygosity of the APC gene in oral squamous cell carcinoma

被引：4

作者：

Rivero, Elena R. C. ^{[1
]}

Horta, Martinho C. R. ^{[2
]}

Guerrae, Eliete N. Silva ^{[3
]}

Ferraz, Alberto R. ^{[4
]}

Nunes, Fabio D. ^{[5
]}

机构：

[1] Univ Fed Santa Catarina, Hlth Sci Ctr, Dept Pathol, BR-88040370 Florianopolis, SC, Brazil

[2] Pontificia Univ Catolica Minas Gerais, Sch Dent, Belo Horizonte, MG, Brazil

[3] Univ Brasilia, Sch Hlth Sci, Dept Dent, Brasilia, DF, Brazil

[4] Univ Sao Paulo, Sch Med, Dept Head & Neck Surg, Sao Paulo, Brazil

[5] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, Sao Paulo, Brazil

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2008年 / 204卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

LOH; Genes; APC; Carcinoma; Squamous cell; PCR; RFLP;

D O I：

10.1016/j.prp.2008.05.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：793 / 797

页数：5

共 50 条

[21] Sequential loss of heterozygosity in the progression of squamous cell carcinoma of the lung
Endo, C
Sagawa, N
Sato, N
Chen, Y
Sakurada, A
Aikawa, H
Takahashi, S
Usuda, K
Saito, Y
Fujimura, S
BRITISH JOURNAL OF CANCER, 1998, 78 (05) : 612 - 615
[22] Sequential loss of heterozygosity in the progression of squamous cell carcinoma of the lung
C Endo
M Sagawa
M Sato
Y Chen
A Sakurada
H Aikawa
S Takahashi
K Usuda
Y Saito
S Fujimura
British Journal of Cancer, 1998, 78 : 612 - 615
[23] LOSS OF HETEROZYGOSITY ON CHROMOSOME 3P IN ORAL PREMALIGNANT LESION AND SQUAMOUS-CELL CARCINOMA
ROZ, L
WU, CL
SPEIGHT, P
PORTER, S
SCULLY, C
THAKKER, NS
JOURNAL OF DENTAL RESEARCH, 1995, 74 (03) : 889 - 889
[24] Loss of heterozygosity at chromosomal areas implicated in the pathogenesis of oral squamous cell carcinoma and its prognostic significance
Pateromichelakis, S
Emilion, G
Phillips, E
Lee, G
Langdon, JD
Partridge, M
ORAL ONCOLOGY, VOL V, 1997, : 401 - 404
[25] Microsatellite instability and loss of heterozygosity in squamous cell carcinoma of the head and neck
Koy, Susanne
Plaschke, Jens
Luksch, Hella
Friedrich, Katrin
Kuhlisch, Eberhard
Eckelt, Uwe
Martinez, Ramon
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2008, 30 (08): : 1105 - 1113
[26] Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma
Sia, HX
Tsao, SW
Poon, CSP
Cheung, ALM
CANCER LETTERS, 2004, 213 (02) : 231 - 239
[27] Loss of heterozygosity at the DCC gene locus is not crucial for the acquisition of metastatic potential in oesophageal squamous cell carcinoma
Maesawa, C
Tamura, G
Ogasawara, S
Suzuki, Y
Sakata, K
Sugimura, J
Nishizuka, S
Sato, N
Ishida, K
Saito, K
Satodate, R
EUROPEAN JOURNAL OF CANCER, 1996, 32A (05) : 896 - 898
[28] Detection of loss of heterozygosity in the APC tumor suppressor gene in nonpapillary renal cell carcinoma by microdissection and polymerase chain reaction
Böhm M.
Wieland I.
Stinhöfer C.
Otto T.
Rübben H.
Urological Research, 1997, 25 (3): : 161 - 165
[29] The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma
Perez-Sayans, Mario
Manuel Suarez-Penaranda, Jose
Herranz-Carnero, Michel
Gayoso-Diz, Pilar
Barros-Angueira, Francisco
Manuel Gandara-Rey, Jose
Garcia-Garcia, Abel
ORAL ONCOLOGY, 2012, 48 (01) : 56 - 60
[30] Status of reduced expression and hypermethylation of the APC tumor suppressor gene in human oral squamous cell carcinoma
Uesugi, H
Uzawa, K
Kawasaki, K
Shimada, K
Moriya, T
Tada, A
Shiiba, M
Tanzawa, H
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2005, 15 (04) : 597 - 602

← 1 2 3 4 5 →