Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

被引：21

作者：

Tran Dinh Thang ^{[1
]}

Kuo, Ping-Chung ^{[2
]}

Huang, Guan-Jhong ^{[3
]}

Nguyen Huy Hung ^{[1
]}

Huang, Bow-Shin ^{[2
]}

Yang, Mei-Lin ^{[4
]}

Ngo Xuan Luong ^{[5
]}

Wu, Tian-Shung ^{[4
]}

机构：

[1] Vinh Univ, Dept Chem, Vinh 42000, Vietnam

[2] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan

[3] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan

[4] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[5] Hong Duc Univ, Dept Nat Sci, Thanhhoa 41000, Vietnam

来源：

MOLECULES | 2013年 / 18卷 / 04期

关键词：

Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage; ENT-KAURENOIC ACID; VASORELAXANT ACTION; ACETOGENIN; BARK;

D O I：

10.3390/molecules18044477

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 +/- 1.2 and 99.8 +/- 0.4 mu M.

引用

收藏

页码：4477 / 4486

页数：10

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