Inflamed fat: what starts the fire?

被引：364

作者：

Neels, JG ^{[1
]}

Olefsky, JM ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 01期

关键词：

D O I：

10.1172/JCI27280

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Obesity is associated with increased macrophage infiltration of adipose tissue, and these macrophages may be an important component of the chromic inflammatory response playing a crucial role in the development of insulin resistance. This prompts the question as to how macrophages infiltrate obese adipose tissue. In this issue of the JCI, Weisberg et al. show the importance of C-C motif chemokine receptor 2 (CCR2) in macrophage recruitment to adipose tissue and the development of obesity and its complications (see the related article beginning on page 115).

引用

页码：33 / 35

页数：3

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