Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

被引：12

作者：

Shiromizu, Takashi ^{[1
]}

Yuge, Mizuki ^{[1
]}

Kasahara, Kousuke ^{[2
]}

Yamakawa, Daishi ^{[2
]}

Matsui, Takaaki ^{[3
]}

Bessho, Yasumasa ^{[3
]}

Inagaki, Masaki ^{[2
]}

Nishimura, Yuhei ^{[1
]}

机构：

[1] Mie Univ, Grad Sch Med, Dept Integrat Pharmacol, Tsu, Mie 5148507, Japan

[2] Mie Univ, Grad Sch Med, Dept Physiol, Tsu, Mie 5145807, Japan

[3] Nara Inst Sci & Technol, Div Biol Sci, Gene Regulat Res, Nara 6300192, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 17期

基金：

日本学术振兴会;

关键词：

ubiquitin-proteasome pathway; cilia; ciliogenesis; differentiation; proliferation; ciliopathy; cancer; VON-HIPPEL-LINDAU; PROTEIN-PROTEIN INTERACTIONS; RIGHT ASYMMETRIC EXPRESSION; PRIMARY CILIA FORMATION; CELLULAR ANTENNA; AURORA-A; CILIOGENESIS; IDENTIFICATION; ACTIVATION; MECHANISMS;

D O I：

10.3390/ijms21175962

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cilia are antenna-like structures present in many vertebrate cells. These organelles detect extracellular cues, transduce signals into the cell, and play an essential role in ensuring correct cell proliferation, migration, and differentiation in a spatiotemporal manner. Not surprisingly, dysregulation of cilia can cause various diseases, including cancer and ciliopathies, which are complex disorders caused by mutations in genes regulating ciliary function. The structure and function of cilia are dynamically regulated through various mechanisms, among which E3 ubiquitin ligases and deubiquitinases play crucial roles. These enzymes regulate the degradation and stabilization of ciliary proteins through the ubiquitin-proteasome system. In this review, we briefly highlight the role of cilia in ciliopathy and cancer; describe the roles of E3 ubiquitin ligases and deubiquitinases in ciliogenesis, ciliopathy, and cancer; and highlight some of the E3 ubiquitin ligases and deubiquitinases that are potential therapeutic targets for these disorders.

引用

页码：1 / 21

页数：21

共 188 条

[11] Identification of the familial cylindromatosis tumour-suppressor gene [J].

Bignell, GR ;

Warren, W ;

Seal, S ;

Takahashi, M ;

Rapley, E ;

Barfoot, R ;

Green, H ;

Brown, C ;

Biggs, PJ ;

Lakhani, SR ;

Jones, C ;

Hansen, J ;

Blair, E ;

Hofmann, B ;

Siebert, R ;

Turner, G ;

Evans, DG ;

Schrander-Stumpel, C ;

Beemer, FA ;

van den Ouweland, A ;

Halley, D ;

Delpech, B ;

Cleveland, MG ;

Leigh, I ;

Leisti, J ;

Rasmussen, S ;

Wallace, MR ;

Fenske, C ;

Banerjee, P ;

Oiso, N ;

Chaggar, R ;

Merrett, S ;

Leonard, N ;

Huber, M ;

Hohl, D ;

Chapman, P ;

Burn, J ;

Swift, S ;

Smith, A ;

Ashworth, A ;

Stratton, MR .

NATURE GENETICS, 2000, 25 (02) :160-165

[12] Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo [J].

Botilde, Yanick ;

Yoshibaa'b, Satoko ;

Shinohara, Kyosuke ;

Hasegawa, Toshiaki ;

Nishimura, Hiromi ;

Shiratori, Hidetaka ;

Hamada, Hiroshi .

DEVELOPMENTAL BIOLOGY, 2013, 381 (01) :203-212

[13] Ciliopathies [J].

Braun, Daniela A. ;

Hildebrandt, Friedhelm .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2017, 9 (03)

[14] A primary cilia-dependent etiology for midline facial disorders [J].

Brugmann, Samantha A. ;

Allen, Nancy C. ;

James, Aaron W. ;

Mekonnen, Zesemayat ;

Madan, Elena ;

Helms, Jill A. .

HUMAN MOLECULAR GENETICS, 2010, 19 (08) :1577-1592

[15] Photoreceptor Cilia and Retinal Ciliopathies [J].

Bujakowska, Kinga M. ;

Liu, Qin ;

Pierce, Eric A. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2017, 9 (10)

[16] Prdx1 promotes the loss of primary cilia in esophageal squamous cell carcinoma [J].

Chen, Qiongzhen ;

Li, Jinmeng ;

Yang, Xiaoning ;

Ma, Junfeng ;

Gong, Fanghua ;

Liu, Yu .

BMC CANCER, 2020, 20 (01)

[17] Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics [J].

Chen, Xiangling ;

Lu, Dayun ;

Gao, Jing ;

Zhu, Hongwen ;

Zhou, Yanting ;

Gao, Daming ;

Zhou, Hu .

JOURNAL OF PROTEOME RESEARCH, 2019, 18 (06) :2654-2665

[18] Homozygosity mapping with SNP arrays identifies TRIM32 an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11) [J].

Chiang, AP ;

Beck, JS ;

Yen, HJ ;

Tayeh, MK ;

Scheetz, TE ;

Swiderski, RE ;

Nishimura, DY ;

Braun, TA ;

Kim, KYA ;

Huang, J ;

Elbedour, K ;

Carmi, R ;

Slusarski, DC ;

Casavant, TL ;

Stone, EM ;

Sheffield, VC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (16) :6287-6292

[19] The demographics of the ubiquitin system [J].

Clague, Michael J. ;

Heride, Claire ;

Urbe, Sylvie .

TRENDS IN CELL BIOLOGY, 2015, 25 (07) :417-426

[20] Autosomal dominant polycystic kidney disease [J].

Cornec-Le Gall, Emilie ;

Alam, Ahsan ;

Perrone, Ronald D. .

LANCET, 2019, 393 (10174) :919-935

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