A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

被引：243

作者：

Caussy, Cyrielle ^{[1
,2
]}

Tripathi, Anupriya ^{[3
,4
,5
,6
]}

Humphrey, Greg ^{[4
]}

Bassirian, Shirin ^{[1
]}

Singh, Seema ^{[1
]}

Faulkner, Claire ^{[1
]}

Bettencourt, Ricki ^{[1
,7
]}

Rizo, Emily ^{[1
]}

Richards, Lisa ^{[1
]}

Xu, Zhenjiang Z. ^{[4
]}

Downes, Michael R. ^{[8
]}

Evans, Ronald M. ^{[8
]}

Brenner, David A. ^{[1
,9
]}

Sirlin, Claude B. ^{[10
]}

Knight, Rob ^{[3
,4
,11
,12
]}

Loomba, Rohit ^{[1
,7
,9
]}

机构：

[1] Univ Calif San Diego, Dept Med, NAFLD Res Ctr, La Jolla, CA 92093 USA

[2] Univ Lyon 1, Hosp Civils Lyon, F-69002 Lyon, France

[3] Univ Calif San Diego, Ctr Microbiome Innovat, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

[6] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[7] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, La Jolla, CA 92093 USA

[8] Salk Inst Biol Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

[9] Univ Calif San Diego, Dept Med, Div Gastroenterol, La Jolla, CA 92093 USA

[10] Univ Calif San Diego, Dept Radiol, Liver Imaging Grp, La Jolla, CA 92037 USA

[11] Univ Calif San Diego, Dept Comp Sci & Engn, La Jolla, CA 92093 USA

[12] Univ Calif San Diego, Dept BioEngn, La Jolla, CA 92093 USA

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

基金：

美国国家卫生研究院;

关键词：

MAGNETIC-RESONANCE ELASTOGRAPHY; ADVANCED FIBROSIS; HEPATIC STEATOSIS; INSULIN-RESISTANCE; ASSOCIATION; STEATOHEPATITIS; MANAGEMENT; HISTOLOGY; RISK; MRI;

D O I：

10.1038/s41467-019-09455-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The presence of cirrhosis in nonalcoholic-fatty-liver-disease (NAFLD) is the most important predictor of liver-related mortality. Limited data exist concerning the diagnostic accuracy of gut-microbiome-derived signatures for detecting NAFLD-cirrhosis. Here we report 16S gut-microbiome compositions of 203 uniquely well-characterized participants from a prospective twin and family cohort, including 98 probands encompassing the entire spectrum of NAFLD and 105 of their first-degree relatives, assessed by advanced magnetic-resonanceimaging. We show strong familial correlation of gut-microbiome profiles, driven by shared housing. We report a panel of 30 features, including 27 bacterial features with discriminatory ability to detect NAFLD-cirrhosis using a Random Forest classifier model. In a derivation cohort of probands, the model has a robust diagnostic accuracy (AUROC of 0.92) for detecting NAFLD-cirrhosis, confirmed in a validation cohort of relatives of proband with NAFLD-cirrhosis (AUROC of 0.87). This study provides evidence for a fecal-microbiomederived signature to detect NAFLD-cirrhosis.

引用

页数：9

共 63 条

[1] Familial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease [J].