Rapid reaction scanning of solid phase chemistry using resins incorporating analytical constructs

被引：27
作者：
Murray, PJ
Kay, C
Scicinski, JJ
McKeown, SC
Watson, SP
Carr, RAE
机构：
[1] Univ Cambridge, Chem Lab, Glaxo Wellcome Cambridge Chem Lab, Cambridge CB2 1EW, England
[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 30期
关键词：
ionisation; labelling; mass spectrometry; solid-phase synthesis;
D O I：
10.1016/S0040-4039(99)01042-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two analytical constructs, based on orthogonally cleavable linkers, are reported which facilitate the mass spectral analysis of solid phase chemistry. The chemical compatibility and orthogonality of the linkers were established in a parallel reaction study using constructs prepared specifically for the purpose. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5609 / 5612
页数：4
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