Effects of Dexamethasone on the Development of Neonatal Rats and Level of Active Caspase-3 in Brain Cortex

被引：7
|
作者：
Menshanov, P. N. [1 ]
Muzyka, V. V. [1 ]
Dygalo, N. N. [2 ]
机构：
[1] Russian Acad Sci, Inst Cytol & Genet, Lab Funct Neurogen, Siberian Div, Novosibirsk 630090, Russia
[2] Novosibirsk State Univ, Dept Physiol, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
neonatal ontogeny; brain; apoptosis; caspase-3; MESSENGER-RNA; DNA FRAGMENTATION; APOPTOSIS; STEM; EXPRESSION; ONTOGENY;
D O I：
10.1007/s10517-012-1745-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Dexamethasone increased the levels of active caspase-3 form in the brain cortex of neonatal rats 120 h after drug administration, but did not affect the expression of this key apoptotic protease in the brain 6 or 24 h postinjection. Increased expression of the active form of caspase-3 in the cerebral cortex was associated with earlier eye opening and delayed formation of startle-reflex in rats.
引用
收藏
页码：478 / 480
页数：3
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