N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

被引：23

作者：

Chen, Yimin ^{[1
]}

Yuan, Chang ^{[1
]}

Xie, Tianxin ^{[1
]}

Li, Yuying ^{[1
]}

Dai, Bin ^{[2
]}

Zhou, Kaixiang ^{[1
]}

Liang, Yi ^{[2
]}

Dai, Jiapei ^{[3
]}

Tan, Hongwei ^{[1
]}

Cui, Mengchao ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China

[2] Wuhan Univ, Coll Lift Sci, State Key Lab Virol, Wuhan 430072, Peoples R China

[3] South Cent Univ Nationalities, Wuhan Inst Neurosci & Neuroengn, Wuhan 430074, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 53期

基金：

中国国家自然科学基金;

关键词：

IN-VIVO DETECTION; PLAQUES; FLUOROPHORES; PATHOLOGY; DEPOSITS; DESIGN;

D O I：

10.1039/d0cc02820g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, a series of organo difluoroboron probes with a BF(2)benzamide moiety was designed, prepared and evaluated. Among them,2cdisplayed the best optical and biological properties, and may be used as a useful near-infrared fluorescent probe for the detection of A beta plaques and neurofibrillary tangles in AD.

引用

页码：7269 / 7272

页数：4

共 26 条

[1] Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease [J].

Barage, Sagar H. ;

Sonawane, Kailas D. .

NEUROPEPTIDES, 2015, 52 :1-18

[2] Smart Near-Infrared Fluorescence Probes with Donor-Acceptor Structure for in Vivo Detection of β-Amyloid Deposits [J].

Cui, Mengchao ;

Ono, Masahiro ;

Watanabe, Hiroyuki ;

Kimura, Hiroyuki ;

Liu, Boli ;

Saji, Hideo .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (09) :3388-3394

[3] Cryo-EM structures of tau filaments from Alzheimer's disease [J].

Fitzpatrick, Anthony W. P. ;

Falcon, Benjamin ;

He, Shaoda ;

Murzin, Alexey G. ;

Murshudov, Garib ;

Garringer, Holly J. ;

Crowther, R. Anthony ;

Ghetti, Bernardino ;

Goedert, Michel ;

Scheres, Sjors H. W. .

NATURE, 2017, 547 (7662) :185-+

[4] Fluorescent Imaging of Amyloid-β Deposits in Brain: An Overview of Probe Development and a Highlight of the Applications for In Vivo Imaging [J].

Fu, Hualong ;

Cui, Mengchao .

CURRENT MEDICINAL CHEMISTRY, 2018, 25 (23) :2736-2759

[5] Amyloid-β Deposits Target Efficient Near-Infrared Fluorescent Probes: Synthesis, in Vitro Evaluation, and in Vivo Imaging [J].

Fu, Hualong ;

Tu, Peiyu ;

Zhao, Liu ;

Dai, Jiapei ;

Liu, Boli ;

Cui, Mengchao .

ANALYTICAL CHEMISTRY, 2016, 88 (03) :1944-1950

[6] Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-β Plaques in Alzheimer's Disease [J].

Fu, Hualong ;

Cui, Mengchao ;

Zhao, Liu ;

Tu, Peiyu ;

Zhou, Kaixiang ;

Dai, Jiapei ;

Liu, Boli .

JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (17) :6972-6983

[7] A century of Alzheimer's disease [J].

Goedert, Michel ;

Spillantini, Maria Grazia .

SCIENCE, 2006, 314 (5800) :777-781

[8] Fibril structure of amyloid-β(1-42) by cryo-electron microscopy [J].

Gremer, Lothar ;

Schoelzel, Daniel ;

Schenk, Carla ;

Reinartz, Elke ;

Labahn, Joerg ;

Ravelli, Raimond B. G. ;

Tusche, Markus ;

Lopez-Iglesias, Carmen ;

Hoyer, Wolfgang ;

Heise, Henrike ;

Willbold, Dieter ;

Schroeder, Gunnar F. .

SCIENCE, 2017, 358 (6359) :116-+

[9]

Groenning Minna, 2010, J Chem Biol, V3, P1, DOI 10.1007/s12154-009-0027-5

[10] Novel D-A-D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease [J].

Li, Yuying ;

Wang, Kan ;

Zhou, Kaixiang ;

Guo, Wentao ;

Dai, Bin ;

Liang, Yi ;

Dai, Jiapei ;

Cui, Mengchao .

CHEMICAL COMMUNICATIONS, 2018, 54 (63) :8717-8720

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