Dose-response analysis of acute oral mucositis and pharyngeal dysphagia in patients receiving induction chemotherapy followed by concomitant chemo-IMRT for head and neck cancer

被引：44
作者：
Bhide, Shreerang A. [1 ,2 ,3 ]
Gulliford, Sarah [2 ,3 ]
Schick, Ulrike [1 ]
Miah, Aisha [1 ]
Zaidi, Shane [1 ]
Newbold, Katie [1 ]
Nutting, Christopher M. [1 ,2 ,3 ]
Harrington, Kevin J. [1 ,2 ,3 ]
机构：
[1] Royal Marsden Hosp, Sutton SM2 5PT, Surrey, England
[2] Inst Canc Res, Sutton, Surrey, England
[3] Inst Canc Res, London SW3 6JB, England
来源：
RADIOTHERAPY AND ONCOLOGY | 2012年 / 103卷 / 01期
关键词：
Dose-response curves; Acute mucositis; Acute dysphagia; Head and neck cancer; Chemo-IMRT; INTENSITY-MODULATED RADIOTHERAPY; LOCALLY ADVANCED HEAD; SQUAMOUS-CELL CARCINOMA; PHASE-III TRIAL; RANDOMIZED-TRIAL; ACCELERATED RADIOTHERAPY; NEOADJUVANT CHEMOTHERAPY; SWALLOWING DYSFUNCTION; CHEMORADIATION; PROLIFERATION;
D O I：
10.1016/j.radonc.2011.12.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Dose-response curves (DRCs) and the quantitative parameters describing these curves were generated for grade 3 oral mucositis and dysphagia in 144 patients using individual patient DVHs. Curve fits to the oral mucositis clinical data yielded parameter values of mean dose in 2 Gy equivalent, MD50 = 51 Gy (95% CI 40-61), slope of the curve, k = 1(95% CI 0.6-1.5). R-2 value for the goodness of fit was 0.80. Fits to the grade 3 dysphagia clinical data yielded parameter values of MD50 = 44.5 Gy (95% CI 36-53), k = 2.6 (95% CI 0.8-4.5). R-2 value for the goodness of fit was 0.65. This is the first study to derive DRCs in patients receiving induction chemotherapy followed by chemo-radiation (IC-C-IMRT) for head and neck cancer. The dose-response model described in this study could be useful for comparing acute mucositis rates for different dose-fractionation schedules when using IMRT for head and neck cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 103 (2012) 88-91
引用
收藏
页码：88 / 91
页数：4
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