Clinical necessity of the immunohistochemical reassessment of para-aortic lymph nodes in resected pancreatic ductal adenocarcinoma

被引:8
作者
Choi, Sung Hoon [1 ,2 ]
Kim, Se Hoon [3 ]
Choi, Jun Jeong [4 ]
Kang, Chang Moo [1 ,2 ]
Hwang, Ho Kyoung [1 ,2 ]
Lee, Woo Jung [1 ,2 ]
机构
[1] Yonsei Univ, Coll Med, Dept Surg, Seoul 120752, South Korea
[2] Severance Hosp, Inst Gastroenterol, Pancreaticobiliary Canc Clin, Seoul, South Korea
[3] Yonsei Univ, Coll Med, Dept Pathol, Seoul 120752, South Korea
[4] Yonsei Univ, Wonju Coll Med, Dept Pathol, Wonju 220050, South Korea
关键词
pancreatic cancer; paraaortic lymph node; micrometastasis; immunohistochemistry; EXTENDED LYMPHADENECTOMY; PERIAMPULLARY ADENOCARCINOMA; PROGNOSTIC INDICATORS; HEAD CANCER; BILE-DUCT; PANCREATICODUODENECTOMY; CARCINOMA; SURVIVAL; MICROMETASTASIS; IMPACT;
D O I
10.3892/ol.2013.1539
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Para-aortic lymph node (PALN) metastasis is widely regarded as a systemic disease in cancer. Undetected PALN micrometastases during routine hematoxylin and eosin (HE) staining may be a cause of poor prognosis following a potentially curative pancreatectomy for pancreatic cancer. In the present study, paraffin-embedded PALN tissue blocks from 99 patients who underwent a pancreatectomy were re-evaluated by immunohistochemical staining using cytokeratin (CK)-19. Patients with PALN metastasis were summarized according to the clinicopathological data. A total of 484 PALNs (median, 4.9 nodes per patient; range, 1-19) were evaluated. PALN metastases were revealed in eight patients (8.1%) by routine HE staining of frozen section biopsies and in one patient (1.0%) by HE staining of a permanent section. Only one patient (1.0%) demonstrated micrometastasis by IHC; this patient did not display any adverse pathological characteristics and had a relatively favorable survival period of 41 months. The present study concluded that an additional reassessment for micrometastasis in PALNs using CK-19 immunohistochemistry (IHC) is not a viable method for determining the survival outcome. A careful examination of a frozen section biopsy is sufficient for attempting curative surgery.
引用
收藏
页码:1189 / 1194
页数:6
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