Total Synthesis of Umuravumbolide and Hyptolide Through Silicon-Tethered Ring-Closing Metathesis

被引：14

作者：

Chowdhury, Partha Sarathi ^{[1
]}

Kumar, Pradeep ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, CSIR, Pune 411008, Maharashtra, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 21期

关键词：

Synthetic methods; Total synthesis; Lactones; Silanes; Metathesis; Wittig reactions; STEREOSELECTIVE-SYNTHESIS;

D O I：

10.1002/ejoc.201300302

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of umuravumbolide and hyptolide has been achieved in a efficient manner by using temporary silicon-tethered ring-closing metathesis and cross-coupling reactions as key steps. The stereogenic centres were generated by means of proline-catalysed -aminoxylation of aldehydes and Brown's asymmetric allylation method.

引用

页码：4586 / 4593

页数：8

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