Aeruginosins, protease inhibitors from the cyanobacterium Microcystis aeruginosa

被引：130

作者：

Ishida, K ^{[1
]}

Okita, Y ^{[1
]}

Matsuda, H ^{[1
]}

Okino, T ^{[1
]}

Murakami, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Marine Biol Lab, Bunkyo Ku, Tokyo 1138657, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 36期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4020(99)00621-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five new protease inhibitors, related to aeruginosins 298-A (5), 98-A (1) and 98-B (2), were isolated from the cyanobacterium Microcystis aeruginosa. Aeruginosins 98-C (3) and 101 (4) differed from 1 in the Hpla unit. Aeruginosin 298-B (6) lacked the argininol unit in 5. Aeruginosins 89-A (7) and 89-B (8) were observed as the tautomers in HPLC because of the presence of the argininal units. Structures 3, 4 and 6-8 were determined on the basis of spectral data and chromatographic analyses of degradation products. The absolute stereochemistry of 1-8 was deduced by a combination of spectral and chemical studies. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：10971 / 10988

页数：18

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