Transcriptional profile of Marek's disease virus genes in chicken thymus during different phases of MDV infection

被引：13

作者：

Hu, Xuming ^{[1
]}

Qin, Aijian ^{[1
,2
]}

Miao, Ji ^{[2
]}

Xu, Wencai ^{[2
]}

Yu, Chuan ^{[2
]}

Qian, Kun ^{[1
,2
]}

Shao, Hongxia ^{[1
,2
]}

机构：

[1] Yangzhou Univ, Minist Educ, Key Lab Avian Prevent Med, Yangzhou 225009, Jiangsu, Peoples R China

[2] Yangzhou Univ, Key Lab Jiangsu Prevent Vet Med, Yangzhou 225009, Peoples R China

来源：

ARCHIVES OF VIROLOGY | 2013年 / 158卷 / 08期

基金：

中国国家自然科学基金;

关键词：

REPLICATION; PRODUCT;

D O I：

10.1007/s00705-013-1665-z

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, 86 Marek's disease virus (MDV) transcripts were detected in chicken thymus infected with RB1B strain. Forty-seven of them, which were mainly involved in viral replication and immune escape, were detected at 7 days postinfection (dpi). Expression of most of the genes was increased at 21 and 28 dpi but reduced or shut down at 14 dpi. Unlike others tissues, we found that a latent infection was established at 14 dpi in infected thymus. Here, we show the kinetics of expression of MDV transcripts and their relative expression in infected thymus.

引用

页码：1787 / 1793

页数：7

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