Effect of zinc oxide nanoparticles on the in vitro degradation of electrospun polycaprolactone membranes in simulated body fluid

被引:80
作者
Augustine, Robin [1 ]
Kalarikkal, Nandakumar [1 ,2 ]
Thomas, Sabu [1 ,3 ]
机构
[1] Mahatma Gandhi Univ, Int & Inter Univ Ctr Nanosci & Nanotechnol, Priyadarshini Hills, Kerala, India
[2] Mahatma Gandhi Univ, Sch Pure & Appl Phys, Priyadarshini Hills, Kerala, India
[3] Mahatma Gandhi Univ, Sch Chem Sci, Priyadarshini Hills, Kerala, India
关键词
Electrospinning; in vitro degradation; PCL; ZnO; CRYSTALLIZATION BEHAVIOR; OXIDATIVE-DEGRADATION; HYDROLYTIC DEGRADATION; DRUG-RELEASE; NANOCOMPOSITES; POLYMERS; FIBERS; POLY(L-LACTIDE); CRYSTALLINITY; MECHANISMS;
D O I
10.1080/00914037.2015.1055628
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Even though the biodegradability of polycaprolactone (PCL) is well established, few studies have carried out on the effect of nanofillers on the in vitro degradability of electrospun PCL membranes. Thus, the authors incorporated common nanofiller zinc oxide (ZnO) nanoparticles in electrospun PCL membranes. From the study of morphological schanges as well as the changes in crystallinity, it is clear that the ZnO nanoparticles accelerated the degradation of PCL. The FTIR results ascertain that the hydrolysis of the PCL nanofibers generates free hydroxyl and carbonyl groups in the bulk of the polymer. The tensile property of the PCL/ZnO nanocomposite membranes decreased with an increase in filler loading during degradation. [GRAPHICS] .
引用
收藏
页码:28 / 37
页数:10
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