A Systematic Review of Altered P300 Event-Related Potential in Apolipoprotein E4 (APOE4) Carriers

被引：4
作者：
Pedroso, Renata Valle [1 ]
Fraga, Francisco Jose [2 ]
Pavarini, Sofia Cristina Iost [1 ]
Nascimento, Carla Manuela Crispim [1 ]
Ayan, Carlos [3 ,4 ]
Cominetti, Marcia Regina [1 ]
机构：
[1] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP, Brazil
[2] Fed Univ ABC UFABC, Engn Modelling & Appl Social Sci Ctr CECS, Santo Andre, SP, Brazil
[3] Univ Vigo, Dept Special Didact, Well Move Res Grp, Vigo, Spain
[4] IIS Galicia Sur, Vigo, Spain
来源：
CLINICAL EEG AND NEUROSCIENCE | 2021年 / 52卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
evoked potentials; Alzheimer's disease; cognition; risk factors; APOE; ALZHEIMERS-DISEASE; E EPSILON-4; METAANALYSIS; INDIVIDUALS; YOUNG; RISK; ERPS; AGE;
D O I：
10.1177/1550059420959966
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background Apolipoprotein epsilon 4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease and seems to be related to cognitive decline and damaged event-related potential P300, which is a sensitive measure to assess cognitive processing. Objective This research aims to critically review the existing scientific evidence regarding the association betweenAPOE4and P300. Methods A systematic review was carried out up to January 2020 on the following databases: Web of Science, Scopus and Medline/PubMed. Articles were considered for inclusion if they are original research that provided information regarding the association betweenAPOE4and P300, available in English, Spanish, or Portuguese, and available in full text. The methodological quality of the studies selected was evaluated using the quality assessment tool for observational cohort and cross-sectional studies recommended by Cochrane. Results Out of 993 studies, 14 met the inclusion criteria. The results obtained showed thatAPOE4is related to a longer P300 latency. However, the data supplied do not allow us to confirm if this relationship also occurs in amplitude measures. Moreover, it was observed thatAPOEgenotype may influence P300 in different ages, from younger individuals to demented older people. Conclusion Evidence shows thatAPOE4negatively influences cortical activities related to cognitive functions, as indicated by P300.
引用
收藏
页码：193 / 200
页数：8
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