Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle

被引：22

作者：

Oh, Dongyep ^{[1
]}

La, Boomi ^{[1
]}

Lee, Yoonseok ^{[2
]}

Byun, Younhwa ^{[1
]}

Lee, Jeayoung ^{[3
]}

Yeo, Geunhye ^{[4
]}

Yeo, Jungsou ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Biotechnol, Gyongsan 712749, Gyeongbuk, South Korea

[2] Inst Charmpoom Hanwoo, Gyongsan 712210, Gyeongbuk, South Korea

[3] Yeungnam Univ, Dept Stat, Gyongsan 712749, Gyeongbuk, South Korea

[4] Green Cross Res Ctr, Yongin 446770, South Korea

来源：

MOLECULAR BIOLOGY REPORTS | 2013年 / 40卷 / 04期

关键词：

Lipoprotein lipase; Korean cattle; Unsaturated fatty acid; Beef flavor; ADIPOSE-TISSUE; JAPANESE; LIPIDS; PALATABILITY; STEERS; BEEF; MEAT;

D O I：

10.1007/s11033-012-2389-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. In this study, genetic associations between fatty acid composition and exonic single nucleotide polymorphisms (SNPs) in the LPL gene were examined using 612 Korean cattle. We investigated the relationship between unsaturated fatty acids and five novel SNPs (c.322G > A, c.329A > T, c.527T > G, c.988C > T and c.1591G > A), and confirmed that three polymorphic SNPs (c.322G > A, c.329A > T and c.1591G > A) were associated with fatty acid composition. Korean cattle with an AA genotype of c.322G > A, c.329A > T, and GA genotype of c.1591G > A had higher levels of monounsaturated fatty acids and carcass traits (P < 0.05). Our findings confirmed that three novel SNPs we identified in the LPL gene can affect fatty acid composition and carcass traits. Therefore, selection for AA and GA genotypes should be recommended to genetically improve beef quality and flavor.

引用

页码：3155 / 3163

页数：9

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