Role of Caco-2 cell monolayers in prediction of intestinal drug absorption

被引：188
作者：
Shah, P
Jogani, V
Bagchi, T
Misra, A
机构：
[1] Maharaja Sayajirao Univ Baroda, Fac Engn & Technol, Dept Pharm, Kalabhavan 390001, Vadodara, India
[2] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Microbiol, Sayajigunj 390002, Vadodara, India
[3] Maharaja Sayajirao Univ Baroda, Fac Sci, Ctr Biotechnol, Sayajigunj 390002, Vadodara, India
来源：
BIOTECHNOLOGY PROGRESS | 2006年 / 22卷 / 01期
关键词：
D O I：
10.1021/bp050208u
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The usefulness of Caco-2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco-2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.
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页码：186 / 198
页数：13
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