Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

被引：72

作者：

Coutinho-Silva, Robson ^{[1
]}

Ojcius, David M. ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Ilha Fundao, BR-21941902 Rio De Janeiro, Brazil

[2] Univ Calif, Hlth Sci Res Inst, Merced, CA 95343 USA

来源：

MICROBES AND INFECTION | 2012年 / 14卷 / 14期

基金：

美国国家卫生研究院;

关键词：

Intracellular pathogens; Danger signals; Extracellular ATP; Purinergic receptors; Inflammasome; Inflammation; NUCLEOSIDE-DIPHOSPHATE-KINASE; VIRULENT MYCOBACTERIUM-TUBERCULOSIS; PURINERGIC RECEPTOR P2X(7); HUMAN MACROPHAGES; TOXOPLASMA-GONDII; DENDRITIC CELLS; INFLAMMASOME ACTIVATION; CHLAMYDIAL INFECTION; INTERNATIONAL UNION; EPITHELIAL-CELLS;

D O I：

10.1016/j.micinf.2012.05.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Extracellular nucleotides are danger signals involved in recognition and control of intracellular pathogens. They are an important component of the innate immune response against intracellular pathogens, inducing the recruitment of inflammatory cells, stimulating secretion of cytokines, and producing inflammatory mediators such as reactive oxygen species (ROS) and nitric oxide (NO). In the case of extracellular ATP, some of the immune responses are mediated through activation of the NLRP3 inflammasome and secretion of the cytokine, interleukin-1 beta (IL-1 beta), through a mechanism dependent on ligation of the P2X7 receptor. Here we review the role of extracellular nucleotides as sensors of intracellular bacteria and protozoan parasites, and discuss how these pathogens manipulate purinergic signaling to diminish the immune response against infection. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：1271 / 1277

页数：7

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