Flipping the script on macrophages in leiomyosarcoma

被引：9

作者：

Edris, Badreddin ^{[1
,2
]}

Weiskopf, Kipp ^{[3
,4
]}

Weissman, Irving L. ^{[1
,3
,4
]}

van de Rijn, Matt ^{[1
]}

机构：

[1] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Ludwig Canc Inst, Stanford, CA 94305 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 07期

关键词：

leiomyosarcoma; tumor-associated macrophages; CSF1; CD47; SIRP alpha; monoclonal antibody cancer therapy; NONGYNECOLOGICAL LEIOMYOSARCOMA; ANGIOGENESIS; PROGRESSION; EXPRESSION; PROTEIN;

D O I：

10.4161/onci.20799

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Macrophages promote the growth of leiomyosarcoma (LMS), a malignant soft-tissue tumor. CD47 on tumor cells binds to the macrophagic receptor signal regulatory protein alpha (SIRP alpha) and prevents phagocytosis. We showed that anti-CD47 monoclonal antibodies (mAbs) allow macrophages to engulf LMS cells and prevent tumor growth and metastases. Therefore, anti-CD47 mAbs represent a promising targeted immunotherapy for LMS.

引用

页码：1202 / 1204

页数：3

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