Effects of zatebradine (ULFS 49 CL), a sinus node inhibitor, on heart rate and exercise duration in chronic stable angina pectoris

被引：44

作者：

Glasser, SP

Michie, DD

Thadani, U

Baiker, WM

机构：

[1] UNIV OKLAHOMA,HLTH SCI CTR,NORMAN,OK 73019

[2] BOEHRINGER INGELHEIM KG,DIV PHARMACEUT RES,INGELHEIM,GERMANY

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1997年 / 79卷 / 10期

关键词：

D O I：

10.1016/S0002-9149(97)00382-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Zatebridine selectively reduces resting and exercise heart rate without any other myocardial effects. In this study, despite significant reductions in resting and exercise heart rate, there were no clinically significant effects on myocardial ischemia, suggesting that the anti-ischemic effect of heart rate reduction should be reevaluated.

引用

收藏

页码：1401 / &

页数：6

相关论文

共 10 条

[1]

DAEMMGEN J W, 1985, Journal of Cardiovascular Pharmacology, V7, P71

[2] PROPERTIES OF THE HYPERPOLARIZING-ACTIVATED CURRENT (IF) IN CELLS ISOLATED FROM THE RABBIT SINOATRIAL NODE [J].

DIFRANCESCO, D ;

FERRONI, A ;

MAZZANTI, M ;

TROMBA, C .

JOURNAL OF PHYSIOLOGY-LONDON, 1986, 377 :61-88

[3] ELIMINATION OF EXERCISE-INDUCED REGIONAL MYOCARDIAL DYSFUNCTION BY A BRADYCARDIAC AGENT IN DOGS WITH CHRONIC CORONARY STENOSIS [J].

GUTH, BD ;

HEUSCH, G ;

SEITELBERGER, R ;

ROSS, J .

CIRCULATION, 1987, 75 (03) :661-669

[4] MECHANISMS OF IMPROVED ISCHEMIC REGIONAL DYSFUNCTION BY BRADYCARDIA - STUDIES ON UL-FS-49 IN SWINE [J].

INDOLFI, C ;

GUTH, BD ;

MIURA, T ;

MIYAZAKI, S ;

SCHULZ, R ;

ROSS, J .

CIRCULATION, 1989, 80 (04) :983-993

[5]

KOBINGER W, 1987, European Heart Journal, V8, P7

[6]

Kobinger W., 1988, CARDIOVASC DRUG REV, V6, P35

[7] CAN EXERCISE-INDUCED REGIONAL CONTRACTILE DYSFUNCTION BE PREVENTED BY SELECTIVE BRADYCARDIC AGENTS [J].

KRUMPL, G ;

SCHNEIDER, W ;

RABERGER, G .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1986, 334 (04) :540-543

[8] COMPARISON OF THE HEMODYNAMIC-EFFECTS OF THE SELECTIVE BRADYCARDIC AGENT UL-FS-49, WITH THOSE OF PROPRANOLOL DURING TREADMILL EXERCISE IN DOGS [J].

KRUMPL, G ;

WINKLER, M ;

SCHNEIDER, W ;

RABERGER, G .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 94 (01) :55-64

[9] EFFECTS OF THE BRADYCARDIC AGENT UL-FS 49 ON EXERCISE-INDUCED REGIONAL CONTRACTILE DYSFUNCTION IN DOGS [J].

RABERGER, G ;

KRUMPL, G ;

SCHNEIDER, W .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 1987, 14 (03) :343-354

[10] SPECIFIC BRADYCARDIC AGENTS, A NEW THERAPEUTIC MODALITY FOR ANESTHESIOLOGY - HEMODYNAMIC-EFFECTS OF UL-FS 49 AND PROPRANOLOL IN CONSCIOUS AND ISOFLURANE-ANESTHETIZED DOGS [J].

RILEY, DC ;

GROSS, GJ ;

KAMPINE, JP ;

WARLTIER, DC .

ANESTHESIOLOGY, 1987, 67 (05) :707-716