An integrated view of cisplatin-induced nephrotoxicity and ototoxicity

被引：406

作者：

Karasawa, Takatoshi ^{[1
]}

Steyger, Peter S. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA

来源：

TOXICOLOGY LETTERS | 2015年 / 237卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Cisplatin; Ototoxicity; Nephrotoxicity; Intracellular mechanisms; SHORT INTERFERING RNA; INDUCED HEARING-LOSS; ACUTE-RENAL-FAILURE; HAIR CELL-DEATH; INDUCED APOPTOSIS; PLATINUM CHEMOTHERAPY; SODIUM THIOSULFATE; COPPER TRANSPORTER; OVARIAN-CARCINOMA; STRIA VASCULARIS;

D O I：

10.1016/j.toxlet.2015.06.012

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and ototoxic side-effects remain major clinical limitations. Recent studies have improved our understanding of the molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. While cisplatin binding to DNA is the major cytotoxic mechanism in proliferating (cancer) cells, nephrotoxicity and ototoxicity appear to result from toxic levels of reactive oxygen species and protein dysregulation within various cellular compartments. In this review, we discuss molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. We also discuss potential clinical strategies to prevent nephrotoxicity and ototoxicity and their current limitations. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：219 / 227

页数：9

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