Quantitation of non-motor symptoms in Parkinson's disease

被引:116
作者
Chaudhuri, K. Ray [1 ,2 ]
Martinez-Martin, P. [3 ]
机构
[1] Kings Coll London, Univ London Kings Coll Hosp, Natl Parkinson Fdn Ctr Excellence, Univ Hosp Lewisham, London, England
[2] Inst Psychiat, London, England
[3] Carlos III Inst Hlth, Natl Ctr Epidemiol, Madrid, Spain
关键词
clinimetrics; non-motor symptoms; Parkinson's disease; questionnaire; scale;
D O I
10.1111/j.1468-1331.2008.02212.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Disabling non-motor symptoms (NMS) associated with Parkinson's disease (PD), such as dementia and loss of balance, do not respond well to levodopa therapy and can lead to eventual death in patients with the disease. In 2006, a multidisciplinary group of experts and patient representatives developed an NMS screening questionnaire (NMSQuest) and a unified Non-Motor Symptoms Scale (NMSS) to address the need for simple identification and comprehensive assessment of NMS in patients with PD. Methods and Results: An international pilot study of 96 healthy controls and 123 patients with various stages of treated and untreated PD was conducted to demonstrate that the NMSQuest is a feasible, valid, and accepted tool. Conclusion: The majority of patients and caregivers felt that the questionnaire was clear and relevant to their daily lives. Data from 242 PD patients with no dementia were analysed in a pilot study on the clinimetric validation of NMSS. Similar to the NMSQuest study, the NMSS study revealed a significant correlation between progression of PD and increasing NMS burden. These studies suggest that the NMSQuest accurately detects the NMS, and that the NMSS closely correlates with quality of life for PD patients.
引用
收藏
页码:2 / 8
页数:7
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