Hyperfractionated radiation combined with chemotherapy in advanced head and neck cancer

被引：0

作者：

Gottardo, C ^{[1
]}

Landmann, C ^{[1
]}

Lohri, A ^{[1
]}

Wolfensberger, M ^{[1
]}

机构：

[1] Univ Basel, Kantonsspital, HNO Klin, CH-4051 Basel, Switzerland

来源：

CURRENT PROBLEMS IN OTOLARYNGOLOGY 21 | 1998年 / 21卷

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D O I：

暂无

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

From 1992 to 1996 41 patients with advanced head and neck cancer were treated with hyperfractionated radiation combined with chemotherapy. There were no severe complications. Because of toxic side effects the treatment had to be stopped in 3 cases and modified in anonther 10 cases. Overall 4-year survival was 46%. Salvage surgery was necessary in 19 patients. Organ preservation was achieved in half of the surviving patients. Ongoing randomized studies will tell us whether hyperfractionated radiation combined with chemotherapy is indeed superior to other treatment modalities.

引用

页码：203 / 212

页数：10

共 9 条

[1] CONCURRENT RADIATION-THERAPY AND CHEMOTHERAPY FOR LOCALLY UNRESECTABLE SQUAMOUS-CELL HEAD AND NECK-CANCER - AN EASTERN-COOPERATIVE-ONCOLOGY-GROUP PILOT-STUDY [J].

ADELSTEIN, DJ ;

KALISH, LA ;

ADAMS, GL ;

WAGNER, H ;

OKEN, MM ;

REMICK, SC ;

MANSOUR, EG ;

HASELOW, RE .

JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (11) :2136-2142

[2]

FIETKAU R, 1997, MODERNE ASPEKTE STRA, P113

[3] CONCURRENT CISPLATINUM AND RADIATION WITH OR WITHOUT SURGERY FOR ADVANCED HEAD AND NECK-CANCER [J].

GLICKSMAN, AS ;

SLOTMAN, G ;

DOOLITTLE, C ;

CLARK, J ;

KONESS, J ;

COACHMAN, N ;

POSNER, M ;

DEROSA, E ;

WANEBO, H .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1994, 30 (05) :1043-1050

[4] HYPERFRACTIONATION VERSUS CONVENTIONAL FRACTIONATION IN OROPHARYNGEAL CARCINOMA - FINAL ANALYSIS OF A RANDOMIZED TRIAL OF THE EORTC COOPERATIVE GROUP OF RADIOTHERAPY [J].

HORIOT, JC ;

LEFUR, R ;

NGUYEN, T ;

CHENAL, C ;

SCHRAUB, S ;

ALFONSI, S ;

GARDANI, G ;

VANDENBOGAERT, W ;

DANCZAK, S ;

BOLLA, M ;

VANGLABBEKE, M ;

DEPAUW, M .

RADIOTHERAPY AND ONCOLOGY, 1992, 25 (04) :231-241

[5]

MILLER AB, 1981, CANCER, V47, P207, DOI 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO

[6]

2-6

[7] RESULTS AFTER ACCELERATED RADIOTHERAPY AND SIMULTANEOUS CARBOPLATINUM APPLICATION IN INOPERABLE CARCINOMAS OF THE HEAD AND NECK REGION [J].

VOLLING, P ;

STAAR, S ;

ECKEL, HE ;

MULLER, RP .

LARYNGO-RHINO-OTOLOGIE, 1994, 73 (10) :511-517

[8] PREOPERATIVE CISPLATIN AND ACCELERATED HYPERFRACTIONATED RADIATION INDUCES HIGH TUMOR RESPONSE AND CONTROL RATES IN PATIENTS WITH ADVANCED HEAD AND NECK-CANCER [J].

WANEBO, HJ ;

GLICKSMAN, AS ;

LANDMAN, C ;

SLOTMAN, G ;

DOOLITTLE, C ;

CLARK, J ;

KONESS, J .

AMERICAN JOURNAL OF SURGERY, 1995, 170 (05) :512-516

[9]

Wendt T. G., 1996, Strahlentherapie und Onkologie, V172, P409

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