Lymphotoxin in physiology of lymphoid tissues - Implication for antiviral defense

被引：21
作者：
Koroleva, Ekaterina P. [1 ,3 ]
Fu, Yang-Xin [2 ]
Tumanov, Alexei V. [1 ,3 ]
机构：
[1] Univ Texas Hlth Sci Ctr San Antonio, Univ Texas Sch Med, Dept Microbiol Immunol & Mol Genet, San Antonio, TX 78229 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX USA
[3] Trudeau Inst, Saranac Lake, NY USA
来源：
CYTOKINE | 2018年 / 101卷
基金：
美国国家卫生研究院;
关键词：
Lymphotoxin; Lymphotoxin beta receptor; Antiviral immunity; Lymphoid organs; Type I interferon; HEPATITIS-C VIRUS; ALPHA-DEFICIENT MICE; TUMOR-NECROSIS-FACTOR; PERSISTENT LCMV INFECTION; I INTERFERON RESPONSE; T-CELL-ACTIVATION; NF-KAPPA-B; LT-BETA-R; VIRAL-INFECTION; LIVER-REGENERATION;
D O I：
10.1016/j.cyto.2016.08.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lymphotoxin (LT) is a member of the tumor necrosis factor (TNF) superfamily of cytokines which serves multiple functions, including the control of lymphoid organ development and maintenance, as well as regulation of inflammation and autoimmunity. Although the role of LT in organogenesis and maintenance of lymphoid organs is well established, the contribution of LT pathway to homeostasis of lymphoid organs during the immune response to pathogens is less understood. In this review, we highlight recent advances on the role of LT pathway in antiviral immune responses. We discuss the role of LT signaling in lymphoid organ integrity, type I IFN production and regulation of protection and immunopathology during viral infections. We further discuss the potential of therapeutic targeting LT pathway for controlling immunopathology and antiviral protection. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：39 / 47
页数：9
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