Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells

被引：34

作者：

Nakata, Susumu ^{[1
]}

Phillips, Emma ^{[2
]}

Goidts, Violaine ^{[2
]}

机构：

[1] Aichi Canc Ctr, Res Inst, Div Oncol Pathol, Nagoya, Aichi, Japan

[2] German Canc Res Ctr, Div Mol Genet, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

来源：

CANCER MANAGEMENT AND RESEARCH | 2014年 / 6卷

关键词：

glioblastoma; colorectal cancer; tissue stem cell marker; MAMMARY-GLAND DEVELOPMENT; ACUTE MYELOID-LEUKEMIA; SMALL-INTESTINE; IN-VITRO; WNT; EXPRESSION; MARKER; EVOLUTION; SARCOMA; COLON;

D O I：

10.2147/CMAR.S57846

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The concept of cancer stem cells has gained considerable interest in the last few decades, partly because of their potential implication in therapy resistance. However, the lack of specific cellular surface markers for these cells has impeded their isolation, making the characterization of this cellular subpopulation technically challenging. Recent studies have indicated that leucine-rich repeat-containing G-protein-coupled receptor 4 and 5 (LGR4 and LGR5) expression in multiple organs may represent a global marker of adult stem cells. This review aims to give an overview of LGR4 and LGR5 as cancer stem cell markers and their function in development.

引用

页码：171 / 180

页数：10

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