Monitoring the antimicrobial susceptibility of Gram-negative organisms involved in intra-abdominal and urinary tract infections recovered during the SMART study (Spain, 2016 and 2017)

被引：0

作者：

Canton, Rafael ^{[1
,2
,3
]}

Loza, Elena ^{[1
,2
]}

Aznar, Javier ^{[4
]}

Javier Castillo, Francisco ^{[5
]}

Cercenado, Emilia ^{[6
,7
]}

Arturo Fraile-Ribot, Pablo ^{[8
,9
]}

Gonzalez-Romo, Fernando ^{[10
]}

Luis Lopez-Hontangas, Jose ^{[11
]}

Rodriguez-Lozano, Jesus ^{[12
,13
]}

Isabel Suarez-Barrenechea, Ana ^{[14
]}

Tubau, Fe ^{[7
,15
,16
]}

Diaz-Reganon, Jazmin ^{[17
]}

Lopez-Mendoza, Diego ^{[17
]}

Rodriguez-Lozano, J. ^{[18
]}

Calvo, J. ^{[18
]}

Tubau, F. ^{[19
]}

Dominguez, M. A. ^{[19
]}

Perez Saenz, J. L. ^{[20
]}

Fraile-Ribot, P. A. ^{[20
]}

Oliver, A. ^{[20
]}

Castillo, F. J. ^{[21
]}

Seral, C. ^{[21
]}

Lopez-Hontangas, J. L. ^{[22
]}

Canton, R. ^{[23
]}

Garcia-Castillo, M. ^{[23
]}

Loza, E. ^{[23
]}

Cercenado, E. ^{[24
]}

Gonzalez Romo, F. ^{[25
]}

Prieto, Jose ^{[25
]}

Aznar, J. ^{[26
]}

Rodriguez-Rey, A. ^{[26
]}

Pascual, A. ^{[27
]}

Suarez-Barrenechea, A., I ^{[27
]}

机构：

[1] Hosp Univ Ramon y Cajal, Serv Microbiol, Carretera Colmenar Km 9,1, Madrid 28034, Spain

[2] IRYCIS, Madrid, Spain

[3] REIPI, Madrid, Spain

[4] Univ Seville, Hosp Univ Virgen del Rocio, Dept Microbiol,Inst Biomed Sevilla,CSIC, Serv Microbiol,Unidad Clin Enfermedades Infeccios, Seville, Spain

[5] Univ Zaragoza, Fac Med, IIS Aragon, Serv Microbiol,Hosp Clin Univ Lozano Blesa, Zaragoza, Spain

[6] Hosp Gen Univ Gregorio Maranon, Serv Microbiol & Enfermedades Infecciosas, Madrid, Spain

[7] Ctr Invest Red Enfermedades Respiratorias CIBERES, Madrid, Spain

[8] Hosp Univ Son Espases, Serv Microbiol, Mallorca, Spain

[9] Inst Invest Sanitaria Islas Baleares IDIS BA, Mallorca, Spain

[10] Hosp Clin San Carlos, Serv Microbiol Clin, Madrid, Spain

[11] Hosp Univ & Politecn La Fe, Serv Microbiol, Valencia, Spain

[12] Hosp Univ Marques Valdecilla, Serv Microbiol, Santander, Spain

[13] Inst Invest Valdecilla IDIVAL, Santander, Spain

[14] Hosp Univ Virgen Macarena, Unidad Gest Clin Enfermedades Infecciosas Microbi, Seville, Spain

[15] Hosp Univ Bellvitge, Serv Microbiol, Barcelona, Spain

[16] Inst Invest Biomed Bellvitge IDIBELL, Barcelona, Spain

[17] Dept Med MSD Espana, Madrid, Spain

[18] Hosp Univ Marques de Valdecilla, Santander, Spain

[19] Hosp Univ Bellvitge IDIBELL, Barcelona, Spain

[20] Hosp Univ Son Espases, Mallorca, Spain

[21] Hosp Clin Univ Lozano Blesa, Zaragoza, Spain

[22] Hosp Univ & Politecn La Fe, Valencia, Spain

[23] Hosp Univ Ramon y Cajal IRYCIS, Madrid, Spain

[24] Hosp Univ Gregorio Maranon, Madrid, Spain

[25] Hosp Clin San Carlos, Madrid, Spain

[26] Hosp Univ Virgen del Rocio, Seville, Spain

[27] Hosp Univ Virgen Macarena, Seville, Spain

来源：

REVISTA ESPANOLA DE QUIMIOTERAPIA | 2019年 / 32卷 / 02期

关键词：

antimicrobial resistance surveillance; intra-abdominal infection; urinary tract infection; extended-spectrum-beta-lactamases; carbapenems; SPECTRUM BETA-LACTAMASES; RESISTANCE TRENDS SMART; ENTEROBACTERIACEAE; MANAGEMENT; EVOLUTION; ERTAPENEM; SURVEILLANCE; PATTERNS;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Introduction. Continuous antimicrobial resistance surveillance is recommended by Public Health authorities. We updated data from the SMART (Study for Monitoring Antimicrobial Resistance Trends) surveillance study in Spain. Material and methods. The antimicrobial susceptibility data and extended-spectrum beta-lactamase (ESBL) production in isolates recovered from intra-abdominal (IAI) (n=1,429) and urinary tract (UTI) (n=937) infections during the 2016-2017 SMART study in 10 Spanish hospitals were analysed. Results. Escherichia coli was the most frequently microorganism isolated (48.3% and 53.7%) followed by Klebsiella spp. (11.5% and 21.9%) in IAIs and UTIs, respectively. Figures for Pseudomonas aeruginosa were 9.0% and 6.1%, being more frequently recovered from patients with nosocomial infections. Overall, 9.9% (IAI) and 14.0% (UTI) of E. coli, Klebsiella spp. and Proteus mirabilis isolates were ESBL-producers, being Klebsiella pneumoniae (34.5%) from UTI of nosocomial origin the most frequent. ESBL-producers were higher in patients >60 years in both IAIs and UTIs. As in previous years, amikacin (96.3%-100% susceptibility), ertapenem (84.2%-100%) and imipenem (70.3%-100%) were the most active antimicrobials tested among Enterobacterales species. The activity of amoxicillin-clavulanic, piperacillin-tazobactam, and ciprofloxacin susceptibility was lower, particularly among ESBL-producers. Ertapenem susceptibility (88.94%-100%) was retained in ESBL-E coli isolates that were resistant to these antimicrobials but decreased (28.64%-100%) in similar isolates of K. pneumoniae. Conclusions. Continuous antimicrobial resistance surveillance from the SMART study reveals overall maintenance of ESBL-producers in Spain, although with higher presence in isolates from UTIs than from IAIs. Moreover, ertapenem activity was high in E. coli irrespective of ESBL production but decreased in K. pneumoniae, particularly among ESBL-producers.

引用

页码：145 / 155

页数：11

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