Distribution of Central Corneal Thickness and its Association with Ocular Parameters in a Large Central European Cohort: The Gutenberg Health Study

被引:46
作者
Hoffmann, Esther M. [1 ]
Lamparter, Julia [1 ]
Mirshahi, Alireza [1 ]
Elflein, Heike [1 ]
Hoehn, Rene [1 ]
Wolfram, Christian [1 ]
Lorenz, Katrin [1 ]
Adler, Max [1 ]
Wild, Philipp S. [2 ]
Schulz, Andreas
Mathes, Barbara
Blettner, Maria [3 ,4 ]
Pfeiffer, Norbert [1 ]
机构
[1] Univ Med Ctr, Dept Ophthalmol, Mainz, Germany
[2] Univ Med Ctr, Dept Internal Med 2, Mainz, Germany
[3] Univ Med Ctr, Dept Internal Med 2, Gutenberg Hlth Study, Mainz, Germany
[4] Univ Med Ctr, Dept Biostat & Epidemiol, Mainz, Germany
来源
PLOS ONE | 2013年 / 8卷 / 08期
关键词
OPEN-ANGLE GLAUCOMA; GOLDMANN APPLANATION TONOMETRY; DYNAMIC CONTOUR TONOMETRY; IN-SITU KERATOMILEUSIS; BLUE MOUNTAINS EYE; INTRAOCULAR-PRESSURE; HYPERTENSION TREATMENT; ULTRASOUND PACHYMETRY; VISUAL IMPAIRMENT; BARBADOS EYE;
D O I
10.1371/journal.pone.0066158
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Main objective: To evaluate the distribution of central corneal thickness (CCT) in a large German cohort and to analyse its relationship with intraocular pressure and further ocular factors. Design: Population-based, prospective, cohort study. Methods: The Gutenberg Health Study (GHS) cohort included 4,698 eligible enrollees of 5,000 subjects (age range 35-74 years) who participated in the survey from 2007 to 2008. All participants underwent an ophthalmological examination including slitlamp biomicroscopy, intraocular pressure measurement, central corneal thickness measurement, fundus examination, and were given a questionnaire regarding glaucoma history. Furthermore, all subjects underwent fundus photography and visual field testing using frequency doubling perimetry. Results: Mean CCT was 557.3 +/- 34.3 mu m (male) and 551.6 +/- 35.2 mu m in female subjects (Mean CCT from right and left eyes). Younger male participants (35-44 years) presented slightly thicker CCT than those older. We noted a significant CCT difference of 4 mu m between right and left eyes, but a high correlation between eyes (Wilcoxon test for related samples: p<0.0001). Univariable linear regression stratified by gender showed that IOP was correlated with CCT (p<0.0001). A 10 mu m increase in CCT led to an increase in IOP between 0.35-0.38 mm Hg, depending on the eye and gender. Multivariable linear regression analysis revealed correlations between gender, spherical equivalent (right eyes), and CCT (p<.0001 and p = 0.03, respectively). Conclusions: We observed positive correlations between CCT and IOP and gender. CCT was not correlated with age, contact lens wear, positive family history for glaucoma, lens status, or iris colour.
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页数:9
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