HIV-1 reverse transcriptase inhibitory activity of flavones and chlorogenic acid derivatives from Moquiniastrum floribundum (Asteraceae)

被引：24

作者：

Tamayose, C. I. ^{[1
]}

Torres, P. B. ^{[2
]}

Roque, N. ^{[3
]}

Ferreira, M. J. P. ^{[2
]}

机构：

[1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo, Brazil

[2] Univ Sao Paulo, Dept Bota, Inst Biociencias, BR-05508090 Sao Paulo, Brazil

[3] Univ Fed Bahia, Inst Biol, BR-40170290 Salvador, BA, Brazil

来源：

SOUTH AFRICAN JOURNAL OF BOTANY | 2019年 / 123卷

基金：

巴西圣保罗研究基金会;

关键词：

Moquiniastrum floribundum; Asteraceae; Flavones; Chlorogenic acid derivatives; HIV-1 reverse transcriptase; L; INFECTION; IDENTIFICATION; DISCOVERY; COMPONENTS; PLANTS;

D O I：

10.1016/j.sajb.2019.02.005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the search for new bioactive natural products, plant sources represent a particularly suitable starting point in drug discovery. Among natural products, phenolic derivatives have a prominent place with several compounds exhibiting remarkable activities. This paper described the phenolic composition of Moquiniastrum floribundum (Asteraceae) and evaluated the inhibitory effect of isolated compounds on HIV-1 reverse transcriptase. From M. floribundum was isolated three flavones, genkwanin (1), hispidulin (2), and cirsimaritin (3), and eight chlorogenic acid derivatives, 4,5-di-O-caffeoylquinic acid (4), 3,5-di-O-caffeoylquinic acid (5), 3,4-di-O-caffeoylquinic acid (6), 3,5-di-O-caffeoylquinic acid methyl ester (7), 3,4,5-tri-O-caffeoylquinic acid methyl ester (8), 3-O-caffeoylquinic acid (9), 4-O-caffeoylquinic acid (10) and 5-O-caffeoylquinic acid (11). The most active compound was 4,5-di-O-caffeoylquinic acid (4), with 65.0 +/- 7.9% of inhibitory activity on HIV-1 reverse transcriptase and IC50 0.240 mmol L-1. (C) 2019 SAAB. Published by Elsevier B.V. All rights reserved.

引用

页码：142 / 146

页数：5