Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases

被引：64

作者：

Cameron, Robert B. ^{[1
,2
]}

Beeson, Craig C. ^{[1
]}

Schnellmann, Rick G. ^{[1
,2
]}

机构：

[1] Med Univ South Carolina, Dept Drug Discovery & Biomed Sci, 280 Calhoun St, Charleston, SC 29425 USA

[2] Univ Arizona, Coll Pharm, 1295 N Martin Ave, Tucson, AZ 85721 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 59卷 / 23期

基金：

美国国家卫生研究院;

关键词：

ACTIVATED PROTEIN-KINASE; SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE SYNTHASE; ACUTE KIDNEY INJURY; RECEPTOR-GAMMA COACTIVATOR-1-ALPHA; ISCHEMIA-REPERFUSION INJURY; ATTENUATES OXIDATIVE STRESS; CYCLIC; 3'; 5'-MONOPHOSPHATE PHOSPHODIESTERASES; HUNTINGTIN-EXPRESSING CELLS; TYPE-2; DIABETES-MELLITUS;

D O I：

10.1021/acs.jmedchem.6b00669

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mitochondria have various roles in cellular metabolism and homeostasis. Because mitochondrial dysfunction is associated with many acute and chronic degenerative diseases, mitochondrial biogenesis (MB) is a therapeutic target for treating such diseases. Here, we review the role of mitochondrial dysfunction in acute and chronic degenerative diseases and the cellular signaling pathways by which MB is induced. We then review existing work describing the development and application of drugs that induce MB in vitro and in vivo. In particular, we discuss natural products and modulators of transcription factors, kinases, cyclic nucleotides, and G protein-coupled receptors.

引用

页码：10411 / 10434

页数：24

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