Nephrogenic systemic fibrosis: A systemic fibrosing disease resulting from gadolinium exposure

被引：64
作者：
Bernstein, Elana J. [2 ,3 ]
Schmidt-Lauber, Christian [4 ]
Kay, Jonathan [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Ctr Rheumatol, UMass Mem Med Ctr, Worcester, MA 01605 USA
[2] Hosp Special Surg, Div Rheumatol, New York, NY 10021 USA
[3] New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Med, New York, NY 10021 USA
[4] Univ Munster, D-48149 Munster, Germany
来源：
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2012年 / 26卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Nephrogenic systemic fibrosis; Gadolinium; GBCA; Magnetic resonance imaging; Chronic kidney disease; Haemodialysis; Peritoneal dialysis; Renal transplantation; NORMAL HUMAN MACROPHAGES; CHRONIC KIDNEY-DISEASE; RENAL-FAILURE; CONTRAST AGENTS; GADODIAMIDE INJECTION; UV-A1; PHOTOTHERAPY; RISK-FACTORS; DERMOPATHY; DIALYSIS; THERAPY;
D O I：
10.1016/j.berh.2012.07.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the history, clinical manifestations, epidemiology, histopathology and pathophysiology of this disabling disease. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：489 / 503
页数：15
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