Nephrogenic systemic fibrosis: A systemic fibrosing disease resulting from gadolinium exposure

被引：65

作者：

Bernstein, Elana J. ^{[2
,3
]}

Schmidt-Lauber, Christian ^{[4
]}

Kay, Jonathan ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Ctr Rheumatol, UMass Mem Med Ctr, Worcester, MA 01605 USA

[2] Hosp Special Surg, Div Rheumatol, New York, NY 10021 USA

[3] New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Med, New York, NY 10021 USA

[4] Univ Munster, D-48149 Munster, Germany

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2012年 / 26卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Nephrogenic systemic fibrosis; Gadolinium; GBCA; Magnetic resonance imaging; Chronic kidney disease; Haemodialysis; Peritoneal dialysis; Renal transplantation; NORMAL HUMAN MACROPHAGES; CHRONIC KIDNEY-DISEASE; RENAL-FAILURE; CONTRAST AGENTS; GADODIAMIDE INJECTION; UV-A1; PHOTOTHERAPY; RISK-FACTORS; DERMOPATHY; DIALYSIS; THERAPY;

D O I：

10.1016/j.berh.2012.07.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the history, clinical manifestations, epidemiology, histopathology and pathophysiology of this disabling disease. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：489 / 503

页数：15

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