Parallel processing by cortical inhibition enables context-dependent behavior

被引：213

作者：

Kuchibhotla, Kishore V. ^{[1
,2
,3
,4
]}

Gill, Jonathan V. ^{[1
,2
,3
,4
]}

Lindsay, Grace W. ^{[5
]}

Papadoyannis, Eleni S. ^{[1
,2
,3
,4
]}

Field, Rachel E. ^{[1
,2
,3
,4
]}

Sten, Tom A. Hindmarsh ^{[1
,2
,3
,4
]}

Miller, Kenneth D. ^{[5
]}

Froemke, Robert C. ^{[1
,2
,3
,4
]}

机构：

[1] NYU, Dept Otolaryngol, Sch Med, Skirball Inst,Neurosci Inst, 550 1St Ave, New York, NY 10016 USA

[2] NYU, Dept Neurosci, Sch Med, Skirball Inst,Neurosci Inst, New York, NY 10016 USA

[3] NYU, Dept Physiol, Sch Med, Skirball Inst,Neurosci Inst, New York, NY 10016 USA

[4] NYU, Ctr Neural Sci, New York, NY 10003 USA

[5] Columbia Univ, Swartz Program Theoret Neurosci, Ctr Theoret Neurosci, Dept Neurosci,Kavli Inst Brain Sci, New York, NY USA

来源：

NATURE NEUROSCIENCE | 2017年 / 20卷 / 01期

关键词：

PRIMARY VISUAL-CORTEX; RECEPTIVE-FIELD PLASTICITY; PRIMARY AUDITORY-CORTEX; DISINHIBITORY MICROCIRCUIT; CHOLINERGIC NEURONS; NUCLEUS BASALIS; TASK; EXCITATION; MODULATION; RESPONSES;

D O I：

10.1038/nn.4436

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Physical features of sensory stimuli are fixed, but sensory perception is context dependent. The precise mechanisms that govern contextual modulation remain unknown. Here, we trained mice to switch between two contexts: passively listening to pure tones and performing a recognition task for the same stimuli. Two-photon imaging showed that many excitatory neurons in auditory cortex were suppressed during behavior, while some cells became more active. Whole-cell recordings showed that excitatory inputs were affected only modestly by context, but inhibition was more sensitive, with PV*, SONI+, and VIP* interneurons balancing inhibition and disinhibition within the network. Cholinergic modulation was involved in context switching, with cholinergic axons increasing activity during behavior and directly depolarizing inhibitory cells. Network modeling captured these findings, but only when modulation coincidently drove all three interneuron subtypes, ruling out either inhibition or disinhibition alone as sole mechanism for active engagement. Parallel processing of cholinergic modulation by cortical interneurons therefore enables context-dependent behavior.

引用

页码：62 / 71

页数：10