Using NMR to identify and characterize natural products

被引：133
作者：
Breton, Rosemary C. [1 ]
Reynolds, William F. [1 ]
机构：
[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
NATURAL PRODUCT REPORTS | 2013年 / 30卷 / 04期
关键词：
ASSISTED STRUCTURE ELUCIDATION; HETERONUCLEAR SHIFT CORRELATION; MAGNETIC-RESONANCE-SPECTROSCOPY; AUTOMATED STRUCTURE ELUCIDATION; FILTER DIAGONALIZATION METHOD; FAST MULTIDIMENSIONAL NMR; C-13; CHEMICAL-SHIFTS; COUPLING-CONSTANTS; HIGH-RESOLUTION; MOLECULAR-STRUCTURE;
D O I：
10.1039/c2np20104f
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the past 28 years there have been several thousand publications describing the use of 2D NMR to identify and characterize natural products. During this time period, the amount of sample needed for this purpose has decreased from the 20-50 mg range to under 1 mg. This has been due to both improvements in NMR hardware and methodology. This review will focus on mainly methodology improvements, particularly in pulse sequences, acquisition and processing methods which are particularly relevant to natural product research, with lesser discussion of hardware improvements.
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页码：501 / 524
页数：24
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