Using NMR to identify and characterize natural products

被引：133

作者：

Breton, Rosemary C. ^{[1
]}

Reynolds, William F. ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

NATURAL PRODUCT REPORTS | 2013年 / 30卷 / 04期

关键词：

ASSISTED STRUCTURE ELUCIDATION; HETERONUCLEAR SHIFT CORRELATION; MAGNETIC-RESONANCE-SPECTROSCOPY; AUTOMATED STRUCTURE ELUCIDATION; FILTER DIAGONALIZATION METHOD; FAST MULTIDIMENSIONAL NMR; C-13; CHEMICAL-SHIFTS; COUPLING-CONSTANTS; HIGH-RESOLUTION; MOLECULAR-STRUCTURE;

D O I：

10.1039/c2np20104f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past 28 years there have been several thousand publications describing the use of 2D NMR to identify and characterize natural products. During this time period, the amount of sample needed for this purpose has decreased from the 20-50 mg range to under 1 mg. This has been due to both improvements in NMR hardware and methodology. This review will focus on mainly methodology improvements, particularly in pulse sequences, acquisition and processing methods which are particularly relevant to natural product research, with lesser discussion of hardware improvements.

引用

页码：501 / 524

页数：24

共 228 条

[101] 2J, 3J-HMBC:: A new long-range heteronuclear shift correlation technique capable of differentiating 2JCH from 3JCH correlations to protonated carbons [J].

Krishnamurthy, VV ;

Russell, DJ ;

Hadden, CE ;

Martin, GE .

JOURNAL OF MAGNETIC RESONANCE, 2000, 146 (01) :232-239

[102] Excitation-sculptured indirect-detection experiment (EXSIDE) for long-range CH coupling-constant measurement [J].

Krishnamurthy, VV .

JOURNAL OF MAGNETIC RESONANCE SERIES A, 1996, 121 (01) :33-41

[103] BUILDUP RATES OF THE NUCLEAR OVERHAUSER EFFECT MEASURED BY TWO-DIMENSIONAL PROTON MAGNETIC-RESONANCE SPECTROSCOPY - IMPLICATIONS FOR STUDIES OF PROTEIN CONFORMATION [J].

KUMAR, A ;

WAGNER, G ;

ERNST, RR ;

WUTHRICH, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (13) :3654-3658

[104] Residual Dipolar Couplings for the Configurational and Conformational Analysis of Organic Molecules [J].

Kummerloewe, G. ;

Luy, B. .

ANNUAL REPORTS ON NMR SPECTROSCOPY, VOL 68, 2009, 68 :193-+

[105] Residual Dipolar Couplings as a Powerful Tool for Constitutional Analysis: The Unexpected Formation of Tricyclic Compounds [J].

Kummerloewe, Grit ;

Crone, Benedikt ;

Kretschmer, Manuel ;

Kirsch, Stefan F. ;

Luy, Burkhard .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (11) :2643-2645

[106] Hadamard NMR spectroscopy [J].

Kupce, E ;

Nishida, T ;

Freeman, R .

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 2003, 42 (3-4) :95-122

[107] Fast multidimensional NMR: Radial sampling of evolution space [J].

Kupce, E ;

Freeman, R .

JOURNAL OF MAGNETIC RESONANCE, 2005, 173 (02) :317-321

[108] Molecular structure from a single NMR experiment [J].

Kupce, Eriks ;

Freernan, Ray .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (32) :10788-10792

[109] Parallel acquisition of two-dimensional NMR spectra of several nuclear species [J].

Kupce, Eriks ;

Freeman, Ray ;

John, Boban K. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (30) :9606-9607

[110] Two-dimensional spectroscopy with parallel acquisition of 1H-X and 19F-X correlations [J].

Kupce, Eriks ;

Cheatham, Steve ;

Freeman, Ray .

MAGNETIC RESONANCE IN CHEMISTRY, 2007, 45 (05) :378-380

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