Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei

被引：40

作者：

Arrighi, Romanico B. G. ^{[1
]}

Ebikeme, Charles ^{[3
]}

Jiang, Yang ^{[2
]}

Ranford-Cartwright, Lisa ^{[3
]}

Barrett, Michael P. ^{[3
]}

Langel, Uelo ^{[2
]}

Faye, Ingrid ^{[1
]}

机构：

[1] Stockholm Univ, Dept Genet Microbiol & Toxicol, S-10691 Stockholm, Sweden

[2] Stockholm Univ, Dept Neurochem, S-10691 Stockholm, Sweden

[3] Univ Glasgow, Glasgow Biomed Res Ctr, Div Infect & Immun, Inst Biomed & Life Sci, Glasgow G12 8TA, Lanark, Scotland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 09期

关键词：

D O I：

10.1128/AAC.01450-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both blood and mosquito stages, and against blood-stage Trypanosoma brucei brucei.

引用

页码：3414 / 3417

页数：4

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