Association of high-risk human papillomavirus with ocular surface squamous neoplasia: a case-control study in Mexico

被引：4

作者：

De La Parra-Colin, Paola ^{[1
]}

Pichardo-Bahena, Raul ^{[2
]}

Mendez-Martinez, Rocio ^{[3
]}

Garcia-Carranca, Alejandro ^{[3
]}

Barrientos-Gutierrez, Tonatiuh ^{[4
]}

Santamaria-Olmedo, Monica ^{[5
]}

Lazcano-Ponce, Eduardo ^{[6
]}

Hidalgo-Bravo, Alberto ^{[4
]}

机构：

[1] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Clin Cornea & Superficie Ocular, Dept Oftalmol, Mexico City, DF, Mexico

[2] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Dept Patol, Mexico City, DF, Mexico

[3] Inst Nacl Cancerol, Unidad Invest Biomed Canc, Mexico City, DF, Mexico

[4] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Dept Genet, Mexico City, DF, Mexico

[5] Inst Nacl Salud Publ, Ctr Invest Salud Publ, Cuernavaca, Morelos, Mexico

[6] Inst Nacl Salud Publ, Secretaria Acad, Cuernavaca, Morelos, Mexico

来源：

SALUD PUBLICA DE MEXICO | 2022年 / 64卷 / 02期

关键词：

squamous cell neoplasms; human papillomavirus; conjunctiva; pterygium; sunburn; OPHTHALMIC PTERYGIUM; CELL CARCINOMA; INFECTION; CANCER; DNA; INTERFERON-ALPHA-2B; HYBRIDIZATION; CONJUNCTIVA; EXPRESSION; VIRUS;

D O I：

10.21149/12796

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective. To investigate the association of high-risk human papilloma virus (HR-HPV) and other risk factors with ocular surface squamous cell neoplasia (OSSN). Materials and methods. We obtained DNA from 22 fresh frozen OSSN tissues and 22 pterygia as controls, we used a broad-spectrum HPV DNA amplification short PCR fragment to identify HPV infection in all specimens and then genotyped HPV by a reverse hybridization line probe assay. We also obtained demographic, sun exposure, and tobacco consumption information. Results. HR-HPV frequency was 40.9% in the OSSN group and 4.5% in the pterygia group (p=0.009). After covariate adjustment, OSSN was associated with HR-HPV (OR=16.3, 95%CI=1.2,218.1, p=0.03) and sunburn (OR=10.8, 95%CI=1.8,86.0, p=0.02). Conclusions. Ocular surface squamous cell neoplasia is a multifactorial disease.The strong association between HR-HPV and OSSN, suggests that HR-HPV could play an etiological role in OSSN development.

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页码：209 / 217

页数：9

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