Association of high-risk human papillomavirus with ocular surface squamous neoplasia: a case-control study in Mexico

被引:4
作者
De La Parra-Colin, Paola [1 ]
Pichardo-Bahena, Raul [2 ]
Mendez-Martinez, Rocio [3 ]
Garcia-Carranca, Alejandro [3 ]
Barrientos-Gutierrez, Tonatiuh [4 ]
Santamaria-Olmedo, Monica [5 ]
Lazcano-Ponce, Eduardo [6 ]
Hidalgo-Bravo, Alberto [4 ]
机构
[1] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Clin Cornea & Superficie Ocular, Dept Oftalmol, Mexico City, DF, Mexico
[2] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Dept Patol, Mexico City, DF, Mexico
[3] Inst Nacl Cancerol, Unidad Invest Biomed Canc, Mexico City, DF, Mexico
[4] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Dept Genet, Mexico City, DF, Mexico
[5] Inst Nacl Salud Publ, Ctr Invest Salud Publ, Cuernavaca, Morelos, Mexico
[6] Inst Nacl Salud Publ, Secretaria Acad, Cuernavaca, Morelos, Mexico
来源
SALUD PUBLICA DE MEXICO | 2022年 / 64卷 / 02期
关键词
squamous cell neoplasms; human papillomavirus; conjunctiva; pterygium; sunburn; OPHTHALMIC PTERYGIUM; CELL CARCINOMA; INFECTION; CANCER; DNA; INTERFERON-ALPHA-2B; HYBRIDIZATION; CONJUNCTIVA; EXPRESSION; VIRUS;
D O I
10.21149/12796
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective. To investigate the association of high-risk human papilloma virus (HR-HPV) and other risk factors with ocular surface squamous cell neoplasia (OSSN). Materials and methods. We obtained DNA from 22 fresh frozen OSSN tissues and 22 pterygia as controls, we used a broad-spectrum HPV DNA amplification short PCR fragment to identify HPV infection in all specimens and then genotyped HPV by a reverse hybridization line probe assay. We also obtained demographic, sun exposure, and tobacco consumption information. Results. HR-HPV frequency was 40.9% in the OSSN group and 4.5% in the pterygia group (p=0.009). After covariate adjustment, OSSN was associated with HR-HPV (OR=16.3, 95%CI=1.2,218.1, p=0.03) and sunburn (OR=10.8, 95%CI=1.8,86.0, p=0.02). Conclusions. Ocular surface squamous cell neoplasia is a multifactorial disease.The strong association between HR-HPV and OSSN, suggests that HR-HPV could play an etiological role in OSSN development.
引用
收藏
页码:209 / 217
页数:9
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