The role of age and cardiovascular disease in glaucomatous optic neuropathy

被引:112
作者
Hayreh, SS [1 ]
机构
[1] Univ Iowa, Coll Med, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA
关键词
ambulatory blood pressure monitoring; anterior ischemic optic neuropathy; blood pressure; glaucoma; glaucomatous optic neuropathy; intraocular pressure; nocturnal arterial hypotension; normal tension glaucoma; optic nerve head ischemia; primary open angle glaucoma;
D O I
10.1016/S0039-6257(99)00018-1
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The role of systemic cardiovascular disorders in glaucomatous optic neuropathy was studied experimentally in rhesus monkeys and clinically in humans. These studies suggest that, in the multifactorial phenomenon of glaucomatous optic neuropathy, among other risk factors, age, cardiovascular disease and nocturnal arterial hypotension may play an important role in the development and progression of glaucomatous optic neuropathy in many cases, independent of intraocular pressure. In glaucomatous optic neuropathy, age may be an indirect index of cardiovascular disease rather than an independent factor per se. Nocturnal arterial hypotension, particularly among hypertensive patients taking oral hypotensive medication, may be an important risk factor. Because 24-hour ambulatory blood pressure monitoring is becoming popular among ophthalmic researchers, multiple confounding factors in ambulatory blood pressure monitoring in patients with optic nerve head ischemic disorders that can produce misleading information are discussed. (C) 1999 by Elsevier Science Inc. All rights reserved.
引用
收藏
页码:S27 / S42
页数:16
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