Post-operative neutrophil-to-lymphocyte ratio and outcome after thrombectomy in acute ischemic stroke

被引:7
作者
Li, Shen-Jie [1 ]
Cao, Shan-Shan [1 ]
Huang, Pei-Sheng [1 ]
Nie, Xin [2 ]
Fu, Yang [1 ]
Liu, Jian-Ren [1 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Stroke Ctr, Dept Neurol,Sch Med, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Biostat Off Clin Res Unit, Sch Med, Shanghai, Peoples R China
关键词
ischemic stroke; mechanical thrombectomy; neutrophil; lymphocyte; outcome; HEMORRHAGIC TRANSFORMATION; NEUROINFLAMMATION; PLATELET; BRAIN;
D O I
10.3389/fneur.2022.990209
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BackgroundNeutrophil to lymphocyte ratio (NLR) is a novel inflammatory marker to predict adverse cardiovascular events. However, there is a lack of data on hemorrhagic transformation (HT) and neurological outcome after mechanical thrombectomy in acute ischemic stroke (AIS). We investigated whether NLR before and after thrombectomy for patients with AIS was associated with HT and neurological outcomes. MethodsWe performed a retrospective analysis of consecutive patients with anterior circulation AIS who underwent thrombectomy. HT was evaluated by CT within 24 h after thrombectomy. Clinical data had been collected retrospectively; laboratory data were extracted from our electronic hospital information system. NLR was obtained at admission (NLR1) and immediately after thrombectomy (NLR2). The main outcomes were post-interventional intracranial hemorrhage and unfavorable functional status (modified Rankin scale scores of 3-6) 3 months post-stroke. ResultsA total of 258 patients with AIS, according to the NIHSS (median 14), were included. NLR2 was higher in patients who developed HT after thrombectomy and unfavorable neurological outcomes 3 months post-stroke (p < 0.001) than in those without HT or favorable outcomes, even after correction for co-factors [Odds Ratio (OR) 1.35 for HT, 95% confidence interval (CI)1.16-1.57, p < 0.001, and 1.85 for unfavorable outcome, 95%CI 1.57-2.17, p < 0.001]. The optimal cutoff value for the NLR2 as an indicator for auxiliary diagnosis of HT and the unfavorable outcome was 8.4 and 8.8, respectively. ConclusionNLR immediately after thrombectomy is a readily available biomarker of HT and neurological outcomes in patients with AIS.
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页数:10
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