Regulation of blood flow in diabetic retinopathy

被引：16
|
作者：
Nippert, Amy R. [1 ]
Newman, Eric A. [1 ]
机构：
[1] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA
来源：
VISUAL NEUROSCIENCE | 2020年 / 37卷
基金：
美国国家卫生研究院;
关键词：
Diabetic retinopathy; neurovascular coupling; blood flow; hypoxia; neurovascular unit; Muller cells; NITRIC-OXIDE SYNTHASE; HEMODYNAMIC-RESPONSE; CAPILLARY PERICYTES; FLICKER STIMULATION; COGNITIVE FUNCTION; RETINAL HYPOXIA; AUTO-REGULATION; OPTIC-NERVE; BRAIN; OXYGEN;
D O I：
10.1017/S0952523820000036
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Blood flow in the retina increases in response to light-evoked neuronal activity, ensuring that retinal neurons receive an adequate supply of oxygen and nutrients as metabolic demands vary. This response, termed "functional hyperemia," is disrupted in diabetic retinopathy. The reduction in functional hyperemia may result in retinal hypoxia and contribute to the development of retinopathy. This review will discuss the neurovascular coupling signaling mechanisms that generate the functional hyperemia response in the retina, the changes to neurovascular coupling that occur in diabetic retinopathy, possible treatments for restoring functional hyperemia and retinal oxygen levels, and changes to functional hyperemia that occur in the diabetic brain.
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页数：8
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