Adipose tissue and breast epithelial cells: A dangerous dynamic duo in breast cancer

被引：168

作者：

Wang, Yuan-Yuan ^{[1
,2
,3
]}

Lehuede, Camille ^{[1
,2
,4
]}

Laurent, Victor ^{[1
,2
]}

Dirat, Beatrice ^{[1
,2
,4
]}

Dauvillier, Stephanie ^{[1
,2
]}

Bochet, Ludivine ^{[1
,2
,4
]}

Le Gonidec, Sophie ^{[2
,4
]}

Escourrou, Ghislaine ^{[5
]}

Valet, Philippe ^{[2
,4
]}

Muller, Catherine ^{[2
]}

机构：

[1] CNRS, Inst Pharmacol & Biol Struct, UMR 5089, F-31077 Toulouse, France

[2] Univ Toulouse, UPS, IPBS, F-31077 Toulouse, France

[3] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, Chongqing, Peoples R China

[4] INSERM, U1048, Inst Natl Sante & Rech Med, F-31432 Toulouse, France

[5] Hop Rangueil, Serv Anatomo Pathol, F-31403 Toulouse, France

来源：

CANCER LETTERS | 2012年 / 324卷 / 02期

关键词：

Adipose tissue; Breast cancer; Microenvironment; Obesity; Inflammation; MURINE MAMMARY-CARCINOMA; MESENCHYMAL STEM-CELLS; OF-THE-LITERATURE; IN-VIVO; TUMOR STROMA; FAT PADS; ADIPOCYTE DIFFERENTIATION; AROMATASE EXPRESSION; GENE-EXPRESSION; GLAND GROWTH;

D O I：

10.1016/j.canlet.2012.05.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Among the many different cell types surrounding breast cancer cells, the most abundant are those that compose mammary adipose tissue, mainly mature adipocytes and progenitors. New accumulating recent evidences bring the tumor-surrounding adipose tissue into the light as a key component of breast cancer progression. The purpose of this review is to emphasize the role that adipose tissue might play by locally affecting breast cancer cell behavior and subsequent clinical consequences arising from this dialog. Two particular clinical aspects are addressed: obesity that was identified as an independent negative prognostic factor in breast cancer and the oncological safety of autologous fat transfer used in reconstructive surgery for breast cancer patients. This is preceded by the overall description of adipose tissue composition and function with special emphasis on the specificity of adipose depots and the species differences, key experimental aspects that need to be taken in account when cancer is considered. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：142 / 151

页数：10

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