Delusions Increase Functional Impairment in Alzheimer's Disease

被引：53
作者：
Fischer, Corinne E. [1 ,2 ,3 ]
Ismail, Zahinoor [3 ,5 ,6 ]
Schweizer, Tom A. [2 ,4 ]
机构：
[1] St Michaels Hosp, Mental Hlth Serv, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada
[2] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada
[3] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[4] St Michaels Hosp, Div Neurosurg, Toronto, ON M5B 1W8, Canada
[5] Ctr Addict & Mental Hlth, Geriatr Mental Hlth Program, Toronto, ON, Canada
[6] Univ Calgary, Dept Psychiat, Calgary, AB, Canada
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2012年 / 33卷 / 06期
关键词：
Dementia; Delusions; Alzheimer's disease; Functional impairment; Caregiver burden; Behaviour; PSYCHOLOGICAL SYMPTOMS; BEHAVIORAL SYMPTOMS; DEMENTIA; PSYCHOSIS; PHARMACOTHERAPY;
D O I：
10.1159/000339954
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background/Aims: Delusions in Alzheimer's disease (AD) may be associated with functional impairment. No studies to date have used functional instruments sensitive to changes in frontal executive function, possibly underestimating the impact. Methods: Patients with AD with and without delusions were administered cognitive tests and questionnaires to assess depression and quality of life. Caregivers were administered questionnaires to assess functional impairment, caregiver burden and behavioural symptoms. Results: AD patients with delusions (n = 19) when compared to AD patients without delusions (n = 19) matched for age, education and global cognitive function were significantly more functionally impaired based on performance on the Disability Assessment for Dementia Scale (p < 0.005). Conclusion: AD patients with delusions have significantly worse functional performance. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码：393 / 399
页数：7
相关论文
共 50 条
  • [41] Impairment of homonymous processing in Alzheimer's disease
    Piccirilli, Massimo
    D'Alessandro, Patrizia
    Micheletti, Norma
    Macone, Sara
    Scarponi, Laura
    Arcelli, Paola
    Petrillo, Stefania Maria
    Silvestrini, Mauro
    Luzzi, Simona
    [J]. NEUROLOGICAL SCIENCES, 2015, 36 (08) : 1331 - 1336
  • [42] Nutraceuticals in cognitive impairment and Alzheimer's disease
    Mecocci, P.
    Tinarelli, C.
    Schulz, R. J.
    Polidori, M. C.
    [J]. FRONTIERS IN PHARMACOLOGY, 2014, 5
  • [43] Olfactory Impairment in Presymptomatic Alzheimer's Disease
    Wilson, Robert S.
    Arnold, Steven E.
    Schneider, Julie A.
    Boyle, Patricia A.
    Buchman, Aron S.
    Bennett, David A.
    [J]. INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE, 2009, 1170 : 730 - 735
  • [44] Vestibular Function Impairment in Alzheimer's Disease
    Nakamagoe, Kiyotaka
    Fujimiya, Suguru
    Koganezawa, Tadachika
    Kadono, Kotarou
    Shimizu, Kotone
    Fujizuka, Natsu
    Takiguchi, Shino
    Ueno, Tomoyuki
    Monzen, Tatsuya
    Tamaoka, Akira
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2015, 47 (01) : 185 - 196
  • [45] Impairment of homonymous processing in Alzheimer’s disease
    Massimo Piccirilli
    Patrizia D’Alessandro
    Norma Micheletti
    Sara Macone
    Laura Scarponi
    Paola Arcelli
    Stefania Maria Petrillo
    Mauro Silvestrini
    Simona Luzzi
    [J]. Neurological Sciences, 2015, 36 : 1331 - 1336
  • [46] The impairment of insulin signaling in Alzheimer's disease
    Candeias, Emanuel
    Duarte, Ana I.
    Carvalho, Cristina
    Correia, Sonia C.
    Cardoso, Susana
    Santos, Renato X.
    Placido, Ana I.
    Perry, George
    Moreira, Paula I.
    [J]. IUBMB LIFE, 2012, 64 (12) : 951 - 957
  • [47] The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
    Weamer, Elise A.
    Emanuel, James E.
    Varon, Daniel
    Miyahara, Sachiko
    Wilkosz, Patricia A.
    Lopez, Oscar L.
    DeKosky, Steven T.
    Sweet, Robert A.
    [J]. INTERNATIONAL PSYCHOGERIATRICS, 2009, 21 (01) : 78 - 85
  • [48] Behavioral symptoms in mild cognitive impairment as compared with Alzheimer's disease and healthy older adults
    Van der Mussele, Stefan
    Le Bastard, Nathalie
    Vermeiren, Yannick
    Saerens, Jos
    Somers, Nore
    Marien, Peter
    Goeman, Johan
    De Deyn, Peter P.
    Engelborghs, Sebastiaan
    [J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2013, 28 (03) : 265 - 275
  • [49] Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment and Alzheimer's disease with dementia
    Siafarikas, Nikias
    Alnaes, Dag
    Monereo-Sanchez, Jennifer
    Lund, Martina J.
    Selbaek, Geir
    Stylianou-Korsnes, Maria
    Persson, Karin
    Barca, Maria Lage
    Almdahl, Ina Selseth
    Fladby, Tormod
    Aarsland, Dag
    Andreassen, Ole A.
    Westlye, Lars T.
    [J]. INTERNATIONAL PSYCHOGERIATRICS, 2021, 33 (11) : 1217 - 1228
  • [50] Cognitive Impairment in Studies of 5HTTLPR and Psychosis in Alzheimer's Disease: A Systematic Review
    Creese, Byron
    Ballard, Clive
    Jones, Emma
    [J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2013, 35 (3-4) : 155 - 164
12345