Delusions Increase Functional Impairment in Alzheimer's Disease

被引：53

作者：

Fischer, Corinne E. ^{[1
,2
,3
]}

Ismail, Zahinoor ^{[3
,5
,6
]}

Schweizer, Tom A. ^{[2
,4
]}

机构：

[1] St Michaels Hosp, Mental Hlth Serv, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada

[2] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada

[3] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[4] St Michaels Hosp, Div Neurosurg, Toronto, ON M5B 1W8, Canada

[5] Ctr Addict & Mental Hlth, Geriatr Mental Hlth Program, Toronto, ON, Canada

[6] Univ Calgary, Dept Psychiat, Calgary, AB, Canada

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2012年 / 33卷 / 06期

关键词：

Dementia; Delusions; Alzheimer's disease; Functional impairment; Caregiver burden; Behaviour; PSYCHOLOGICAL SYMPTOMS; BEHAVIORAL SYMPTOMS; DEMENTIA; PSYCHOSIS; PHARMACOTHERAPY;

D O I：

10.1159/000339954

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: Delusions in Alzheimer's disease (AD) may be associated with functional impairment. No studies to date have used functional instruments sensitive to changes in frontal executive function, possibly underestimating the impact. Methods: Patients with AD with and without delusions were administered cognitive tests and questionnaires to assess depression and quality of life. Caregivers were administered questionnaires to assess functional impairment, caregiver burden and behavioural symptoms. Results: AD patients with delusions (n = 19) when compared to AD patients without delusions (n = 19) matched for age, education and global cognitive function were significantly more functionally impaired based on performance on the Disability Assessment for Dementia Scale (p < 0.005). Conclusion: AD patients with delusions have significantly worse functional performance. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：393 / 399

页数：7

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