Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors

被引：47

作者：

Martin, David P. ^{[1
]}

Cohen, Seth M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 43期

基金：

美国国家卫生研究院;

关键词：

MATRIX-METALLOPROTEINASE INHIBITORS; ERYTHROCYTE ISOZYMES I; VITRO INHIBITION; ACTIVE-SITE; SERIES; BINDING; PHENOLS;

D O I：

10.1039/c2cc32013d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors.

引用

页码：5259 / 5261

页数：3

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