What is life?: The paradigm of DNA and protein cooperation at high local concentrations

被引：7

作者：

Müller-Hill, B ^{[1
]}

机构：

[1] Univ Cologne, Inst Genet, D-50674 Cologne, Germany

来源：

MOLECULAR MICROBIOLOGY | 2006年 / 60卷 / 02期

关键词：

D O I：

10.1111/j.1365-2958.2006.05126.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many chemical reactions need high concentrations of the molecules involved in order to work efficiently. It is usually impossible for the cell to achieve the necessary high concentrations of all relevant molecules in unconfined solutions but this becomes possible if the high concentration is restricted around a relevant molecule. High local concentrations of interacting molecules have been observed many times in many different biological systems. The examples of Lac and Lambda repressors of Escherichia coli are presented and discussed here as useful paradigms of mechanisms for achieving high local concentrations of interacting protein protomers.

引用

页码：253 / 255

页数：3

共 22 条

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