Angiogenesis in hematologic malignancies and its clinical implications

Angiogenesis is defined as a neoformation of blood vessels of capillary origin. Hematopoiesis is closely Linked with angiogenesis, for they share a common ancestor, the hemangioblast. Although it is well established that growth in solid tumors is dependent on angiogenesis, its role in hematologic malignancies has not yet been clarified. In this review, the direct evidence, ie, increased microvessel density, and the indirect evidence, ie, elevated level of angiogenic factors or overexpression of messenger RNA or protein of angiogenic factors, for and against the role of angiogenesis in the development and progression of hematologic malignancies are presented. (C)2002 The Japanese Society of Hematology.